Evidence map›Paper›PMID 40510845›Full record

ArticleBiomaterials research2025

Autophagy-Regulating, Photothermal Polydopamine-Coated, and Photodynamic Zirconium/Porphyrin-Framed Metal-Organic Frameworks for Enhanced Doxorubicin Therapy in Colon Cancer.

Junghan Lee, Kwangsun Yu, Enkhzaya Davaa, Ratchapol Jenjob, Phuong Hoa Tran, Dahee Ryu, Jongyoon Kim, Seongju Lee, Zheyu Shen, Wha-Seung Ahn and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Junghan LeeDepartment of Biomedical Science, BK21 FOUR Program in Biomedical Science and Engineering, Inha University College of Medicine, Incheon 22332, Republic of Korea.
Kwangsun YuCarbon Neutral Demo-Plant Center, Korea Research Institute of Chemical Technology (KRICT), Yeosu-si59631, Republic of Korea.
Enkhzaya DavaaDepartment of Biomedical Science, BK21 FOUR Program in Biomedical Science and Engineering, Inha University College of Medicine, Incheon 22332, Republic of Korea.
Ratchapol JenjobDepartment of Biomedical Science, BK21 FOUR Program in Biomedical Science and Engineering, Inha University College of Medicine, Incheon 22332, Republic of Korea.
Phuong Hoa TranDepartment of Biomedical Science, BK21 FOUR Program in Biomedical Science and Engineering, Inha University College of Medicine, Incheon 22332, Republic of Korea.
Dahee RyuDepartment of Biomedical Science, BK21 FOUR Program in Biomedical Science and Engineering, Inha University College of Medicine, Incheon 22332, Republic of Korea.
Jongyoon KimDepartment of Biomedical Science, BK21 FOUR Program in Biomedical Science and Engineering, Inha University College of Medicine, Incheon 22332, Republic of Korea.
Seongju LeeDepartment of Biomedical Science, BK21 FOUR Program in Biomedical Science and Engineering, Inha University College of Medicine, Incheon 22332, Republic of Korea.
Zheyu ShenSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong 510515, China.
Wha-Seung AhnDepartment of Chemical Engineering, Inha University, Incheon 22201, Republic of Korea.
Chung-Sung LeeDepartment of Pharmaceutical Engineering, Soonchunhyang University, Chungcheongnam-do 31538, Republic of Korea.
Su-Geun YangDepartment of Biomedical Science, BK21 FOUR Program in Biomedical Science and Engineering, Inha University College of Medicine, Incheon 22332, Republic of Korea.ORCID https://orcid.org/0000-0001-5278-8723

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metal-organic frameworks (MOFs) have immense potential for biomedical applications. This paper reports the development of multifunctional zirconium-based metal-organic framework (ZrMOF) nanohybrids, featuring a photodynamic porphyrin-framed zirconium cluster with photothermal polydopamine (PD) coating. The PD-coated ZrMOF (PD/ZrMOF) nanohybrids exhibit enhanced colloidal stability and biocompatibility. The PD/ZrMOF nanohybrids in the present study exhibited a unique combination of functionalities, including photodynamic therapy (PDT), photothermal therapy (PTT), and the delivery of anticancer agents. Furthermore, hydrazone-modified doxorubicin (DOX-hyd) was encapsulated within the PD/ZrMOF nanohybrids, enabling a pH-responsive release mechanism that responds to acidic conditions within the tumor microenvironment. This study examined how MOFs influence autophagy, which is essential for maintaining cellular homeostasis in various human diseases, resulting in autophagy activation by MOF treatment. Additional research into the possible mechanisms of autophagy by MOF showed that the up-regulation of Beclin-1 and ATG7, independent of the mTOR pathway, contributes to autophagy induction. Furthermore, the DOX-hyd-encapsulated PD/ZrMOF nanohybrids (DOX-hyd-PD/ZrMOF) exhibited remarkable cancer suppression ability in vitro and in vivo, owing to their tri-mode therapeutic capabilities comprising PDT, PTT, and chemotherapy. This versatile "three-in-one" nanoplatform enables efficient cancer imaging and offers a powerful strategy for multi-mode combination treatments.

Identifiers

PMID40510845
PMCPMC12160315

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.