ArticleMaterials today. Bio2025
Engineering 3D-BMSC exosome-based hydrogels that collaboratively regulate bone microenvironment and promote osteogenesis for enhanced cell-free bone regeneration.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Injectable hydrogels for bone regeneration: from materials design to clinical translation.RSC advances · 2026Review
- Reprogramming the Aging Type H Vascular Niche via Myeloid Angiogenic Cell-Derived Extracellular Vesicles: Mechanisms, Engineering Strategies, and Translational Perspectives.International journal of molecular sciences · 2026Review
- Bee sting-shaped microneedles for accelerating Achilles tendinopathy healing via enhanced regulating macrophage polarization.Journal of nanobiotechnology · 2026Article
- Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone-Related Diseases.Cell proliferation · 2026Review
- A Biocompatible Microdroplet Platform Incorporating MSC-Derived Exosomes for Bone Regeneration and Osteoporosis Treatment.International journal of nanomedicine · 2026Article
- Therapeutic Potential of Exosomes in Bone Infection: Mechanisms of Action, Engineering Strategies, and Translational Applications.International journal of nanomedicine · 2026Review
- Hydrogel scaffold encapsulating MSC-Exos and ZIF-8 promotes bone regeneration via coordinating osteogenesis and immunomodulation.Bioactive materials · 2025Article
- Exosomal Interventions in Bone and Osteochondral Repair: Mechanisms and Outcomes.International journal of molecular sciences · 2025Review
- Immunocyte-derived extracellular vesicles in osteoimmunology: mechanisms, disease contexts, and translational prospects.Frontiers in immunology · 2025Review
- Transcriptomic Profiling Reveals NF-κB-Associated Immune Regulatory Signatures Underlying the Regenerative Effects of Hypoxia-Preconditioned Tendon Stem Cell-Derived Extracellular Vesicles.BioFactors (Oxford, England)Article
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Authors and funding
6 authors.
Funding
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Abstract
Large bone defects are a significant clinical challenge due to their frequent failure to heal spontaneously. Recently, BMSC-derived exosomes (Exo) based cell-free bone regeneration offer several distinct advantages over BMSCs themselves in the repair of damaged tissue, including enhanced repair ability and superior biocompatibility, which can be further augmented under 3D-cultured conditions. However, their therapeutic efficacy for bone regeneration is significantly constrained by hypoxic bone microenvironment and short retention time in bone defect region. Thus, judiciously regulating bone microenvironment and extending retention time are crucial for bone regeneration. Herein, we developed Superparamagnetic Iron Oxide Nanoparticles (SPION) -modified 3D-cultured Exo, termed as 3D-SExo, to enhance Reactive Oxygen Species (ROS) scavenging and promote bone regeneration in response to the needs of bone defect. After entrapment in bone-targeting peptide-modified GelMA (Gel-DSS6), the composite hydrogel (3D-SExo/DGel) was obtained, which can prolong the retention of exosomes, and thereby enhancing bone repair ability. In addition, miR-122-5p, detected via microRNA (miRNA) array from 3D-cultured Exo, were observed to promote osteogenesis by activating Wnt/β-catenin pathway, which was further verified by miRNA transfection. Through the
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