Evidence map›Paper›PMID 40510785›Full record

ArticleFrontiers in allergy2025

Fluticasone propionate in chronic rhinosinusitis with nasal polyps (CRSwNP): an artificial intelligence-driven consensus.

Emilio Avallone, Raffaella Iannella, Antonella Di Lullo, Michele Grasso, Salvatore Musto, Enzo Piermichele Troncone, Giuseppe Tortoriello, Bernardino Cassiano, Simona Nappi, Gianluca Bava and 18 more

Abstract read
In one paragraph

Article in Frontiers in allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Building bridges in migraine management: consensus pathways on best practices across primary and specialist care in Italy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Emilio AvalloneDepartment of Otolaryngology, AORN "San Pio", Benevento, Italy.
Raffaella IannellaDepartment of Otolaryngology, AORN "San Pio", Benevento, Italy.
Antonella Di LulloDepartment of Otolaryngology, AORN "San Pio", Benevento, Italy.
Michele GrassoDepartment of Otolaryngology, AORN "San Pio", Benevento, Italy.
Salvatore MustoDepartment of Otolaryngology, AORN "San Pio", Benevento, Italy.
Enzo Piermichele TronconeCEO, Butterfly Decisions S.r.l., Salerno, Italy.
Giuseppe TortorielloDepartment of Otolaryngology, AORN "Ospedale dei Colli", Napoli, Italy.
Bernardino CassianoDepartment of Otolaryngology, Asl NA 3- Nola (NA), Nola, Italy.
Simona NappiDepartment of Otolaryngology, Asl NA 3- Nola (NA), Nola, Italy.
Gianluca BavaSimple Departmental Operational Unit of ENT, G. Paolo II Hospital - Lamezia Terme (CZ), Lamezia Terme, Italy.
Giovanna PiazzettaDepartment of Medical and Surgical Sciences, Department of Otolaryngology, "Renato Dulbecco" University Hospital, Catanzaro, Italy.
Giovanni TomacelliDepartment of General and Specialized Surgery, Department of Otolaryngology, ASL Lecce Vito Fazzi Hospital, Lecce, Italy.
Aurelio D'EcclesiaDepartment of Otolaryngology, Irccs Casa Sollievo Della Sofferenza San Giovanni Rotondo, Foggia, Italy.
Giacomo SpinatoDepartment of Neurosciences, Otolaryngology Unit, University of Padova, Padova, Italy.
Giacomo MatroneHead of Data Science and AI, Butterfly Decisions, Salerno, Italy.
Doriano PolitiDepartment of Otolaryngology, "Ospedale Dell'Angelo Mestre ULSS3 Serenissima", Mestre, Italy.
Carlo De LucaFisioter Medical Center, ENT Division, Montecilfone Campobasso, Italy.
Claudio CaporaleDepartment of Otolaryngology, "Santo Spirito Hospital", Pescara, Italy.
Livio PresuttiDepartment of Otolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.
Gabriele MolteniDepartment of Otolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.
Ernesto PasquiniDepartment of Specialist Surgery, ENT Unit, "Bellaria" Hospital, Bologna, Italy.
Francesco PanuDepartment of Otolaryngology, Policlinico Città di Quartu, Korian Kinetica Sardegna, Quartu, Italy.
Simonetta MasieriScienze Odontostomatologiche e Maxillo Facciale Department, Sapienza University, Roma, Italy.
Stefano Di GirolamoOtolaryngology Department, Tor Vergata University, Rome, Italy.
Giulio Cesare PassaliUnit of Otorhinolaryngology and Head-Neck Surgery, "A. Gemelli" Hospital Foundation IRCCS, Rome, Italy.
Luca de CamporaDepartment of Otolaryngology, Azienda Ospedaliera S. Giovanni Addolorata, Roma, Italy.
Giandomenico MaggioreDepartment Otolaryngology Head and Neck Surgery, AOU Careggi Firenze, Firenze, Italy.
Domenico Di MariaDepartment of Otolaryngology, AORN "San Pio", Benevento, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Fluticasone propionate (FP) is a topical corticosteroid used to treat rhinosinusitis with nasal polyposis (CRSwNP). However, the need for a consensus on its use stems from the increasing focus on optimizing topical therapies to improve clinical outcomes and minimize systemic side effects. Materials and methods: The Butterfly Decisions AI platform facilitated the collection and integration of evaluations and feedback, facilitating an expert consensus on 13 statements. Results: The participants agreed highly on the different statements. The experts agreed that FP effectively reduces the need for surgery and controls the symptoms of CRSwNP. The use of advanced delivery systems significantly improved drug delivery and therapeutic outcomes. Treatment with FP was associated with a reduction in the recurrence of nasal polyps and an improvement in the patient's quality of life. Conclusions: FP, as other equal corticosteroids, represents a first-line local therapy for patients with CRSwNP without complicating comorbidities due to its high efficacy and low systemic bioavailability. The Butterfly Decisions platform has demonstrated the effectiveness of integrating AI tools into clinical decision-making, improving the transparency and objectivity of assessments.

Indexed as

butterflyconsensusCRSwNPfluticasonenasal drops

Identifiers

PMID40510785
PMCPMC12159040

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.