Evidence map›Paper›PMID 40510771›Full record

ReviewJournal of Taibah University Medical Sciences2025

Current trends and future prospects of N-acetylcysteine utilizations in Parkinson's disease: A literature network analysis.

Muthmainah Muthmainah, Nanang Wiyono, Faris K Syah, Adityas Purnianto, Ratih D Yudhani, Brian Wasita

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of Taibah University Medical Sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Redefining the role of the thiol-based agentRSC medicinal chemistry · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Muthmainah MuthmainahDepartment of Anatomy, Faculty of Medicine, Universitas Sebelas Maret, Indonesia.
Nanang WiyonoDepartment of Anatomy, Faculty of Medicine, Universitas Sebelas Maret, Indonesia.
Faris K SyahDepartment of Neurology, Faculty of Medicine, Universitas Sebelas Maret, Indonesia.
Adityas PurniantoThe Florey Institute, The University of Melbourne, Australia.
Ratih D YudhaniDepartment of Pharmacology, Faculty of Medicine, Universitas Sebelas Maret, Indonesia.
Brian WasitaDepartment of Pathological Anatomy, Faculty of Medicine, Universitas Sebelas Maret, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a prevalent neurodegenerative disorder without a definitive cure. Oxidative stress is significantly implicated in its pathogenesis, prompting interest in N-acetylcysteine (NAC), a strong antioxidant and cysteine precursor, as a potential therapeutic agent. We conducted a bibliometric analysis of 421 Scopus articles to assess current trend and future potential of research on the use of NAC in Parkinson's disease. The number of publications related to this topic reached the peaked in 2010 and gradually decreased afterward. We identified 4 main clusters of research theme related to the potential mechanism of NAC effects on Parkinson's disease progression. These include research focusing on NAC effects on oxidative stress, dysfunction of the mitochondria, aberrant protein accumulation and clearance and inflammation. Investigating NAC effect for Parkinson's disease in human is a potential research area.

Indexed as

Bibliometric analysisN-acetylcysteineNetwork analysisParkinson's disease

Identifiers

PMID40510771
PMCPMC12162018

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.