ArticleTobacco induced diseases2025
Smoking-related bladder cancer burden from 1990 to 2021: An age-period-cohort analysis of the global burden of disease study.
Article in Tobacco induced diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Secondary primary tumors following iodine-125 low-dose-rate brachytherapy for localized prostate cancer.International journal of clinical oncology · 2026Article
- Galactokinase 1 Inhibition-Induced Cell Cycle Arrest and Apoptosis in Bladder Cancer Cells Is Associated with AKT Signaling Downregulation.International journal of molecular sciences · 2026Article
- Diseases burden and trends of bladder cancer attributable to behavioral and metabolic factors among global and Chinese population, 1990-2021: results from the global burden of disease study 2021.Journal of health, population, and nutrition · 2025Article
- Smoking promotes the progression of bladder cancer through FOXM1/CKAP2L axis.Journal of translational medicine · 2025Article
- Emerging Role of Multiparametric MRI in the Staging of Bladder Cancer: Insights From the BladderPath Trial.Cureus · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBladder cancer is common in the elderly, with smoking as a major risk factor. This study assesses the global burden of bladder cancer attributable to smoking, using data from 204 countries and regions (1990-2021).
methodsMortality, age-standardized mortality rates (ASMR), disability-adjusted life years (DALYs), and age-standardized DALY rates (ASDR) were extracted from the Global Burden of Disease (GBD) 2021 study. The burden of smoking-related bladder cancer was analyzed by age, gender, and sociodemographic index (SDI).
resultsBetween 1990 and 2021, global deaths due to smoking-related bladder cancer increased by 42.9%, while disability rose by 31.0%. In 2021, the global number of bladder cancer deaths due to smoking reached 58766 (95% UI: 49381-70891). Despite these increases, both ASMR and ASDR declined globally. Males experienced a higher increase in mortality and disability, with rates approximately 10 times higher than females. Middle SDI countries saw the largest rise in burden. The annual decline in mortality was 2.06%, greater in males than females.
conclusionsThe burden of smoking-related bladder cancer is higher in males, middle-aged and elderly individuals, and medium to high SDI countries. Targeted prevention and health policies are crucial to reducing the disease's impact on populations and healthcare systems.
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