ArticleFrontiers in microbiology2025
Association between oral microbiome diversity and kidney stones: a cross-sectional study.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Article
- Multi-habitat microbiome profiling identifies habitat-dependent alterations and complementary discriminatory information in urolithiasis.Frontiers in cellular and infection microbiology · 2026Article
- Clinical risk factors and machine learning-assisted interpretation of ureteral access sheath insertion failure: a multicenter study and meta-analysis.Frontiers in surgery · 2026Article
- Construction and validation of a risk prediction model for oral frailty in rural hypertensive patients.Frontiers in public health · 2026Article
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Authors and funding
12 authors.
Funding
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Abstract
Background: Kidney stones are a common urologic disorder that imposes a significant burden on global public health. This study aimed to determine the association between oral microbiome diversity and kidney stones. Methods: The data for this study came from the National Health and Nutrition Examination Survey 2009-2012 survey cycle. Use of alpha diversity to assess oral microbiome diversity. Multivariate logistic regression modeling was used to assess the association between different alpha-diversity indicators and kidney stones. Subgroup analyses and interaction tests were used to assess the stability of the association between alpha-diversity and kidney stones. Restricted cubic spline plots were used to assess non-linear associations and dose-response relationships. Results: The study included 5,870 eligible participants with a mean age of 43.74 years at baseline. After adjusting for all covariates, the observed oral microbiome diversity was significantly negatively associated with the risk of kidney stones ( Conclusions: In this study, we found an inverse relationship between oral microbiome diversity and kidney stone risk observed in alpha diversity. This reveals the complexity of host-microbiome interactions, and further mechanistic studies are necessary to elucidate these complex roles in the future.
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