Evidence map›Paper›PMID 40510646›Full record

ArticleInternational journal of particle therapy2025

Feasibility of Utilizing Spot-Scanning Proton Arc (SPArc) for Whole-Lung Irradiation: A Case Report.

Peilin Liu, Lewei Zhao, Gang Liu, Xi Cao, An Qin, Di Yan, Xiaoqiang Li, Craig Stevens, Rohan Deraniyagala, Xuanfeng Ding

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of particle therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Peilin LiuDepartment of Radiation Oncology, Beaumont Health System, Royal Oak, MI 48084, USA.
Lewei ZhaoDepartment of Radiation Oncology, Beaumont Health System, Royal Oak, MI 48084, USA.
Gang LiuDepartment of Radiation Oncology, Beaumont Health System, Royal Oak, MI 48084, USA.
Xi CaoDepartment of Radiation Oncology, Beaumont Health System, Royal Oak, MI 48084, USA.
An QinDepartment of Radiation Oncology, Beaumont Health System, Royal Oak, MI 48084, USA.
Di YanDepartment of Radiation Oncology, Beaumont Health System, Royal Oak, MI 48084, USA.
Xiaoqiang LiDepartment of Radiation Oncology, Beaumont Health System, Royal Oak, MI 48084, USA.
Craig StevensDepartment of Radiation Oncology, Beaumont Health System, Royal Oak, MI 48084, USA.
Rohan DeraniyagalaDepartment of Radiation Oncology, Beaumont Health System, Royal Oak, MI 48084, USA.
Xuanfeng DingDepartment of Radiation Oncology, Beaumont Health System, Royal Oak, MI 48084, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Photon radiotherapy is the conventional method in the treatment of bilateral whole-lung metastasis. However, uncertainties, longer delivery times, large lateral penumbra, and motion interplay limit intensity-modulated proton therapy (IMPT)'s use in bilateral lung metastases. To overcome such limitations in IMPT, this study explores the feasibility of using a novel proton therapy technique, Spot-scanning Proton Arc (SPArc) therapy, to improve the dose sparing to the heart and other healthy tissue for this pediatric patient compared to the volumetric modulated arc therapy (VMAT) and IMPT. Patients and Methods: A 13-year-old patient with a malignant neoplasm of bone and articular cartilage, presenting with bilateral whole-lung metastasis, received whole-lung irradiation of 15 Gy in 10 fractions using VMAT. For comparative analysis, plans were generated using IMPT and SPArc. Results: The study showed that SPArc was superior in sparing the heart and enhancing delivery efficiency compared to both VMAT and IMPT. The mean heart dose was 5.41 Gy for SPArc, 8.48 Gy for IMPT, and 9.56 Gy for VMAT. D50 of the heart was 3.06 Gy for SPArc, 9.13 Gy for IMPT, and 9.12 Gy for VMAT. The integral body dose was 137 Gy·L in VMAT,189 Gy·L in IMPT, and 98 Gy·L in SPArc. Conclusion: Spot-scanning proton arc demonstrated effective heart sparing and lower body-integral dose for whole-lung irradiation. Delivery simulations suggested improved efficiency compared with IMPT.

Indexed as

Pediatric cancerProton arcWhole-lung irradiation

Identifiers

PMID40510646
PMCPMC12162079

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