ArticleJournal of experimental orthopaedics2025
Growth differentiation factor 5 improves meniscal healing in a pilot study on rats.
Article in Journal of experimental orthopaedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Intra-Articular Injection of Parathyroid Hormone (1-34) Enhances Meniscal Healing at the Site of a Radial Tear in the Rabbit Medial Meniscus.International journal of molecular sciences · 2026Article
- Good mid-term outcomes and over 80% survivorship rate after all-inside repair of bucket-handle and full-thickness radial tears.Journal of experimental orthopaedics · 2026Article
- Growth differentiation factor 5 improves meniscal healing in a pilot study on rats.Journal of experimental orthopaedics · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Meniscus injuries are common, but failed repairs remain an issue. The aim of this study was to demonstrate, in an in vivo rat model, the ability of growth differentiation factor 5 (GDF5) to improve meniscal tear healing. Methods: Eight Lewis rats (four females and four males) underwent radial tear of the medial meniscus on the right knee. There were two post-operative treatments: the GDF5 group ( Results: In the R-R zone, the median [interquartile range, IQR] MHS was 2.5 [2-3] in the GDF5 group and 2 [1.25-2] in the saline group ( Conclusions: GDF5 increases meniscal healing, especially in the R-W zone, although the W-W zone remains challenging. GFD5 is a promising factor for improving meniscus healing. The small sample size and absence of biomechanical evaluation are limitations that warrant caution when interpreting these findings. Further studies with larger sample sizes in larger animal models, combined with meniscal repair, are required to confirm these preliminary results. Study Design: Animal laboratory study. Level of Evidence: Level V, animal study.
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