ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
The impact of mild cognitive impairment on healthcare utilization and costs: A UK Biobank study.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative efficacy and certainty of evidence of exercise interventions for cognitive outcomes in older adults with mild cognitive impairment: a systematic review and network meta-analysis of randomized controlled trials.Frontiers in aging neuroscience · 2026Pooled it
- Trial
- Cognitive impairment and hospital admission risk among community-dwelling adults in the MAUCO cohort.Annals of medicine · 2026Article
- Combined Effects of PFAS and Metals on Cognitive Function.Environments (Basel, Switzerland) · 2026Article
- Article
- Developing an effective care model to empower caregivers to use a humanoid companion robot: an exploratory qualitative study.Frontiers in public health · 2025Article
- The impact of mild cognitive impairment on healthcare utilization and costs: A UK Biobank study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMild cognitive impairment (MCI) is common in older adults, but the burden on patients and health systems is not well understood. We aimed to estimate the impact of MCI on healthcare utilization and costs.
methodsThis was a matched cohort study in UK Biobank comparing healthcare costs and Alzheimer's disease (AD) dementia incidence rates in participants with MCI to propensity score-matched participants without MCI.
resultsOf 164,508 eligible participants, 6605(4%) had cognitive testing scores consistent with MCI. Ten-year inpatient costs were 7.6% higher in MCI versus matched no-MCI participants, while 6-year primary care costs were 9.1% higher. Among MCI participants, AD dementia incidence rates were substantially higher than in non-MCI participants (7.2 5-year incidence rate ratio 95% CI: 3.3 to 15.7), and eventual AD dementia accrued higher additional inpatient costs (mean £20,199) over 10 years. DISCUSSION: MCI is characterized by modestly higher healthcare utilization and costs. Subsequent AD dementia diagnosis was strongly associated with costs. Highlights: Baseline cognitive tests identified individuals with all-cause MCI in the UK Biobank.We compared individuals with MCI to propensity score-matched participants without MCI.Inpatient costs were 7.6% higher over 10 years, and primary care costs were 9.1% higher over 6 years for participants with MCI.AD dementia incidence rate ratio was 7.2 higher in participants with MCI.Among MCI participants, eventual AD dementia was a key driver of costs resulting in higher inpatient costs (mean £20,199) over 10 years.
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