ArticleBrain & spine2025
Quality of life assessment in schwannomatosis - A systematic review.
Article in Brain & spine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Development and Initial Validation of the Quality of life Evaluation inmedRxiv : the preprint server for health sciences · 2026Article
- Changes in quality of life and work status after surgical management of meralgia paresthetica- an observational cohort study.Brain & spine · 2026Article
- "It's not any one thing, it's always all of them, all at the same time": quality of life in NF2-related schwannomatosis from patient and clinician perspectives.Familial cancer · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The term schwannomatosis refers to rare genetic disorders characterized by the development of multiple tumors within the central and/or peripheral nervous system. Recent advancements in our molecular understanding of these disorders have led to a redefined conceptual framework within the field, grouping NF2-related schwannomatosis with other forms of schwannomatosis. Research question: This systematic review aims to compile and analyse existing literature on QoL in individuals with schwannomatosis. Methods: A comprehensive search of electronic databases was conducted up until January 2025. Inclusion criteria included studies evaluating QoL in adults with schwannomatosis, using validated QoL assessment tools or patient-reported outcome measures. There were no geographical or time restrictions placed on the search. Case reports and reviews were excluded from the analysis to focus on original research contributions. Results: The initial search identified 241 articles, after removal of duplicates. Three articles were added after screening references. 40 articles were selected for final analysis. These studies utilized various assessment tools, including PHQ-9 (n = 10), WHOQOL-BREF (n = 9) and the disease-specific questionnaire NFTI-QOL (n = 15). The collective findings consistently indicated compromised QoL among individuals with schwannomatosis, particularly in domains such as physical functionality, pain perception, emotional well-being, and social interactions. Discussion and conclusion: This systematic review reveals substantial variability in QoL assessment for schwannomatosis, highlighting significant physical and psychological impacts in NF2-SWN and predominant bodily pain in non-NF2-SWN patients. We call for an international, interdisciplinary consensus on standardized QoL tools to enable clearer research comparisons, guide clinical practice, and improve patient-centered care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.