Evidence map›Paper›PMID 40510547›Full record

ArticleAmerican heart journal plus : cardiology research and practice2025

Supersaturated oxygen therapy using radial artery access to prevent left ventricular remodeling after anterior ST-segment elevation myocardial infarction: a randomized, controlled trial.

Francis R Joshi, Maria Petty, Yen Wing Ng, Hamish Elliott, Ross Anderson, Douglas Gordon, Rebecca Hanna, Robert Sykes, Shaun Leonard, Andrew Morrow and 8 more

Registry-linked trialAbstract read
In one paragraph

Article in American heart journal plus : cardiology research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06662890 (Supersaturated Oxygen Therapy Using Radial Artery Access to Prevent Left Ventricular Remodeling After Anterior ST-segment Elevation Myocardial Infarction), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06662890 narecruitingnot on this map

Supersaturated Oxygen Therapy Using Radial Artery Access to Prevent Left Ventricular Remodeling After Anterior ST-segment Elevation Myocardial Infarction: a Randomized, Controlled Trial

TypeinterventionalSponsorNHS National Waiting Times Centre BoardRan2024 to 2038Enrolled56ConditionsMyocardial Infarct, Remodeling, Left VentricleArmsSupersaturated oxygen, Sham (No Treatment)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Francis R JoshiNHS Golden Jubilee National Hospital, Clydebank, United Kingdom.
Maria PettyNHS Golden Jubilee National Hospital, Clydebank, United Kingdom.
Yen Wing NgNHS Golden Jubilee National Hospital, Clydebank, United Kingdom.
Hamish ElliottNHS Golden Jubilee National Hospital, Clydebank, United Kingdom.
Ross AndersonNHS Golden Jubilee National Hospital, Clydebank, United Kingdom.
Douglas GordonNHS Golden Jubilee National Hospital, Clydebank, United Kingdom.
Rebecca HannaNHS Golden Jubilee National Hospital, Clydebank, United Kingdom.
Robert SykesNHS Golden Jubilee National Hospital, Clydebank, United Kingdom.
Shaun LeonardNHS Golden Jubilee National Hospital, Clydebank, United Kingdom.
Andrew MorrowNHS Golden Jubilee National Hospital, Clydebank, United Kingdom.
Dylan TanNHS Golden Jubilee National Hospital, Clydebank, United Kingdom.
Anna KamdarNHS Golden Jubilee National Hospital, Clydebank, United Kingdom.
Ramu PerumalZOLL Medical Corporation, Chelmsford, MA, United States.
Jeffrey L CreechZOLL Medical Corporation, Chelmsford, MA, United States.
Peter KellmanNational Heart Lung and Blood Institute, Bethesda, MD, United States.
Paul WelshBritish Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
Alex McConnachieRobertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom.
Colin BerryNHS Golden Jubilee National Hospital, Clydebank, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Novel strategies to limit the size of infarction and prevent adverse remodeling and heart failure in patients following acute ST-segment elevation myocardial infarction (STEMI) are lacking. Supersaturated oxygen (SSO Objectives: To assess the primary outcome, defined as the within-participant change in the plasma concentration of NT-proBNP measured at baseline, 24 h, 2-5 days and 3-months post-MI. Design: Prospective, randomized, controlled, blinded, endpoint (mechanistic, PROBE) clinical trial. Randomized controlled trial: After primary PCI, eligible participants will be blinded and randomized 2:1 to either 1 h of SSO Value: The study will test the feasibility of radial artery access, provide mechanistic data and inform a larger multicenter trial powered to detect treatment effects on clinical endpoints.Clinicaltrials.gov: NCT06662890.

Indexed as

Heart failureSTEMISupersaturated oxygenTransradial

Identifiers

PMID40510547
PMCPMC12162053

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.