ArticleFrontiers in nutrition2025
Evaluating the link between the dietary intake of vitamin B and constipation: a population-based study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Prior research has established a correlation between dietary micronutrient intake and the risk of developing constipation. However, the potential link between vitamin B intake and constipation has yet to be fully explored. This study sought to assess the association between chronic constipation and dietary vitamin B intake based on National Health and Nutrition Examination Survey (NHANES) data. Methods: This study employed NHANES data collected between 2005 and 2010, including a total of 13,885 participants 20 + years of age. Dietary intake of vitamins B1, B2, niacin, B6, folic acid, choline, and B12 was assessed using the first 24-h dietary recall interview. Constipation was defined based on the Bristol Stool Form Scale (BSFS). A weighted logistic regression model and restricted cubic spline (RCS) analysis were utilized to adjust for demographic and lifestyle-related variables and probe the relationship between B vitamin intake and constipation. Statistical significance was set at a two-tailed Results: The analysis revealed a nonlinear inverse correlation between dietary intake of all examined B vitamins and constipation risk. In particular, a significant reduction in constipation odds was observed in the highest intake quartiles of niacin (OR = 0.76, 95% CI: 0.59-0.99, p for trend = 0.003), folate (OR = 0.61, 95% CI: 0.48-0.79, p for trend < 0.001), and choline (OR = 0.77, 95% CI: 0.60-1.00, p for trend = 0.05) when using a model that was fully adjusted. Subgroup analyses further indicated that alcohol consumption significantly modified the relationship between folate (p for interaction = 0.003), vitamin B1 (p for interaction = 0.004), niacin (p for interaction = 0.04), choline (p for interaction = 0.02), and constipation. Conclusion: Increased dietary intake of B vitamins may contribute to a reduced risk of constipation, particularly among specific population subgroups. These results offer additional support for the potential role of dietary modifications in promoting gut health.
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