Observational studyFrontiers in endocrinology2025
Extraocular muscle index as a novel indicator of inflammatory condition in graves' ophthalmopathy patients.
Observational study in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- MRI-based evaluation of orbital structures in relation to thyroid function in thyroid eye disease.Endocrine · 2026Article
- Advancements in imaging research in thyroid-associated ophthalmopathy.Frontiers in endocrinology · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study utilized the extraocular muscle index measured through computed tomography (CT) to objectively assess the condition of immune inflammation in patients with Graves' ophthalmopathy. Methods: This observational study included 50 control subjects and 50 patients diagnosed with graves' ophthalmopathy (GO). The study collected mean platelet volume (MPV) alongside other serological indicators. Additionally, thyroid function parameters, clinical activity score (CAS), and NOSPECS score were documented. In the enrolled patients, the total extraocular muscle thickness was assessed using CT at the mid-orbital region posterior to the eyeball, with measurements obtained using Image-J software. The objective of this study was to investigate the inflammatory condition by analyzing the correlation between extraocular muscle thickness and blood indices, thereby providing a reliable predictor for clinical outcomes. Results: In patients with GO, the levels of neutrophil count (NC), lymphocyte count (LC), and platelet distribution width (PDW) were significantly elevated compared to the control group (p=0.024, p=0.016, and p=0.004, respectively). Conversely, the MPV exhibited a significant decrease (p=0.005). A linear regression analysis indicated a positive correlation between MPV and extraocular muscle thickness (r=1.356, p=0.014). Notably, MPV retained a positive correlation with extraocular muscle thickness even after adjusting for potential confounding factors such as age, CAS, NOSPEC, and thyroid function. Conclusion: The extraocular muscle index serves as a reliable predictor of the overall inflammatory status in patients with GO. Consequently, we can effectively assess the systemic inflammatory status of GO patients through orbital CT, thereby providing valuable references for clinical intervention.
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