ArticleMalaysian family physician : the official journal of the Academy of Family Physicians of Malaysia2025
A rare case report of delayed thyroxine hypersensitivity: Challenges and management strategies.
Article in Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Herein, we present the case of a 45-year-old woman with a history of Graves' disease who underwent radioactive iodine therapy and was prescribed different oral preparations of thyroxine. Despite initial tolerance to the medication, she developed hypersensitivity reactions 3 months after consumption, which presented as urticarial rashes, erythematous maculopapular eruptions and angio-oedema. She tried a different preparation of thyroxine accompanied by antihistamines but continued having persistent reactions. This led to her discontinuation of thyroxine, resulting in overt hypothyroidism with secondary dyslipidaemia and weight gain. A diagnosis of delayed thyroxine hypersensitivity was made based on history, clinical assessment and supportive evidence from the Naranjo Adverse Drug Reaction Probability Scale.
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