ArticleToxicology reports2025
Protective effect of omega-3 on reducing doxorubicin toxicity in preclinical trials.
Article in Toxicology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Nutritional Prevention of Oxidative Stress-Induced Cardiotoxicity in Pediatric Cardio-Oncology: Molecular Mechanisms and Translational Perspectives-A Narrative Review.International journal of molecular sciences · 2026Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of chemotherapeutic agents, such as doxorubicin, is often associated with severe adverse effects, making it essential to develop therapeutic strategies that can attenuate or reduce their toxicity. This study aimed to investigate the effects of omega-3 in mitigating the damage induced by doxorubicin. Rabbits received doxorubicin (1 mg/kg, twice weekly for six weeks) with or without omega-3 (500, 1000, or 2000 mg/kg), administered concomitantly. An additional group received omega-3 alone (2000 mg/kg). Hematological, biochemical, genotoxic (micronucleus assay), cardiological (electrocardiogram, echocardiogram, and markers), and histopathological parameters were assessed. Os resultados mostraram que o tratamento com doxorrubicina isolada induziu caquexia nos animais. O tratamento com ômega-3 melhora parâmetros como ganho de peso, fração de ejeção cardíaca, encurtamento sistólico ventricular, marcadores cardíacos CK-MB e Troponina I, área do ventrículo esquerdo e parâmetros histopatológicos (inflamação, edema, dano celular e fibras musculares), sugerindo um efeito protetor. Além disso, o ômega-3 exibiu atividade antigenotóxica, evidenciada pela redução de micronúcleos. Esses achados indicam que o ômega-3 pode servir como um complemento eficaz à quimioterapia, reduzindo a toxicidade da doxorrubicina.
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Registered trials
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