ArticleJournal of pathology informatics2025
Digital morphometry illustrates a relationship between percentage of ductal carcinoma in-situ in breast needle core biopsy and margin status at lumpectomy.
Article in Journal of pathology informatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Candidates for breast conserving surgery are selected based on imprecise variables and there is uncertainty surrounding the risk of complicated margins. Earlier estimates made with light microscopy revealed the correlation between percentage of needle core biopsy ductal carcinoma in-situ and positive lumpectomy margin status. We now study this association utilizing the precision of digital pathology. One hundred and seventy-nine lumpectomy specimens of pure ductal neoplasia were identified and their pathological, clinical, and radiological parameters retrieved. Each lumpectomy had a corresponding needle core biopsy for histological review. Virtually all cases exhibited a luminal A phenotype. Eighty-three cases showed positive margins and ninety-six cases, negative margins. We used the 2019 American College of Breast Surgeons Lumpectomy Consensus Guidelines to define margin status. For each case, by analog microscopy, we selected a single needle core biopsy slide with the greatest absolute quantity of carcinoma in-situ; each selected slide was submitted for digital whole slide imaging. Digital images were manually annotated for carcinoma in-situ, invasive carcinoma, stroma, and fat strictly based on morphology. Morphometric variables were compiled and compared to the corresponding lumpectomy margin status. Increases in percent ductal carcinoma in-situ are associated with greater odds of positive lumpectomy margins (
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