Evidence map›Paper›PMID 40510393›Full record

ArticleJournal of clinical biochemistry and nutrition2025

Analysis of serum zinc level in patients with severe trauma.

Hanna Kavaliova, Shuhei Yamano, Shimon Murahashi, Shuntaro Sato, Yurika Kawazoe, Eri Uemura, Takanobu Otaguro, Hiroo Izumino, Takamitsu Inokuma, Goro Tajima and 3 more

Abstract read
In one paragraph

Article in Journal of clinical biochemistry and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hanna KavaliovaDisaster and Radiation Medical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
Shuhei YamanoCoordination Office for Emergency Medicine and International Response, Acute and Critical Care Center, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Shimon MurahashiAcute and Critical Care Center, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Shuntaro SatoClinical Research Center, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Yurika KawazoeClinical Research Center, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Eri UemuraAcute and Critical Care Center, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Takanobu OtaguroAcute and Critical Care Center, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Hiroo IzuminoAcute and Critical Care Center, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Takamitsu InokumaAcute and Critical Care Center, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Goro TajimaAcute and Critical Care Center, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Kazunori YamashitaAcute and Critical Care Center, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Koichi HayakawaCoordination Office for Emergency Medicine and International Response, Acute and Critical Care Center, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Osamu TasakiAcute and Critical Care Center, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc plays a role in immune function. This study aimed to investigate the clinical significance of zinc levels in patients with severe trauma by examining the association between serum zinc levels and infectious complications. Inclusion criteria were hospitalization of 2 weeks or more; Abbreviated Injury Scale score of 3 or more; zinc levels measured on admission and at 2 weeks later. Among the 141 included patients on admission, 136 (96.5%) had zinc deficiency, whereas at two weeks later, serum zinc levels increased significantly, with the number of patients with zinc deficiency decreasing to 31 (22.0%). Between the zinc-deficient group and zinc-sufficient group stratified by serum zinc level at two weeks, there were significant differences in lengths of ICU stay and mechanical ventilation, the complication of infection, and positive blood cultures. Logistic regression showed that zinc level at two weeks after admission were significantly associated with the complication of infection (

Indexed as

infectious complicationserum zinc levelsevere traumazinc deficiencyzinc supplementation

Identifiers

PMID40510393
PMCPMC12152239

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.