ArticleBioinformatics advances2025
Causeway: a pipeline for genome-wide effector gene screening with Mendelian Randomization and colocalization.
Article in Bioinformatics advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Summary: The integration of quantitative trait loci and disease genome-wide association studies for pinpointing candidate causal genes is a computationally demanding task accompanied by pitfalls related to the methods used. To address these issues, we introduce Causeway, a novel Nextflow pipeline for performing summary statistics-based two sample Mendelian Randomization for causal gene prioritization. The pipeline executes sensitivity and colocalization analyses for interrogation of findings providing robust results. The tool is designed to run tasks in a computationally efficient way even in low-resource environments, such as a personal computer. Furthermore, it can scale to web servers and high-performance computing clusters. Availability and implementation: The source code of Causeway is available at GitHub https://github.com/juliaapolonio/Causeway, while the documentation and instructions to run the vignette at https://juliaapolonio.github.io/Causeway/.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.