Evidence map›Paper›PMID 40510360›Full record

ArticleFrontiers in immunology2025

Dynamic alterations of circulating lymphocytes during the trajectory of Hantaan virus-induced hemorrhagic fever with renal syndrome.

Lin Su, Shuangjuan Liu, Lei Shi, Yuan Cheng, Juanjuan Gao, Ruirui Guo, Yinli He, Linpei Zhang, Tianyan Chen, Jinsong Hu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lin Su *Infectious Diseases Department, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Shuangjuan Liu *Medical Laboratory, Weinan Central Hospital, Weinan, Shaanxi, China.
Lei Shi *Infectious Diseases Department, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Yuan ChengDepartment of Breast Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Juanjuan GaoBioBank, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Ruirui GuoBioBank, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Yinli HeBioBank, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Linpei ZhangBioBank, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Tianyan ChenInfectious Diseases Department, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Jinsong HuDepartment of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Xiaojiao LiBioBank, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Yawen WangBioBank, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hemorrhagic fever with renal syndrome (HFRS) is a zoonotic disease with high mortality. Almost 90% of global cases of HFRS are induced by Hantaan virus (HTNV) infection. Although lymphocyte dysfunction is a critical factor in HFRS progression, the specific immune dynamics of HTNV remain unexplored, and current analyses predominantly depend on single-time point sampling. Therefore, comprehensive longitudinal studies are needed to characterize circulating lymphocyte dynamics during HTNV-induced HFRS progression. Methods: In this study, we conducted a flow cytometric analysis of circulating lymphocytes in 39 patients with HTNV-induced HFRS across different clinical phases. The analysis encompassed conventional T cells, unconventional T cells, B cells, NK cells and their respective repertoires. Results and Discussion: Here, we revealed phase-specific immune patterns: CD8

Indexed as

Hantaan virusHemorrhagic Fever with Renal SyndromeLymphocytesAdultAgedFemaleHumansMaleMiddle Agedbiomarkersdynamic alterationsHFRSHTNVlymphocyte subsets

Identifiers

PMID40510360
PMCPMC12159035

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.