Evidence map›Paper›PMID 40510334›Full record

ArticleCase reports in oncology

Unexpected Twin Pregnancy in a BRCA2-Positive Breast Cancer Patient with Post-Chemotherapy Amenorrhea: A Case Report and Call for Comprehensive Contraceptive Counseling.

Rui Omori, Kenji Gonda, Megumi Arai, Toyoaki Sawano, Tomohiro Kurokawa, Yutaka Tamada, Ayu Yasui, Mika Nashinoto, Masahiro Wada, Kazunoshin Tachibana and 4 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rui OmoriBreast and Thyroid Center, Jyoban Hospital of Tokiwa Foundation, Iwaki, Japan.
Kenji GondaBreast and Thyroid Center, Jyoban Hospital of Tokiwa Foundation, Iwaki, Japan.
Megumi AraiDepartment of Nursing, Jyoban Hospital of Tokiwa Foundation, Iwaki, Japan.
Toyoaki SawanoDepartment of Surgery, Jyoban Hospital of Tokiwa Foundation, Iwaki, Japan.
Tomohiro KurokawaDepartment of Surgery, Jyoban Hospital of Tokiwa Foundation, Iwaki, Japan.
Yutaka TamadaDepartment of Gynecology, Jyoban Hospital of Tokiwa Foundation, Iwaki, Japan.
Ayu YasuiBreast and Thyroid Center, Jyoban Hospital of Tokiwa Foundation, Iwaki, Japan.
Mika NashinotoDepartment of Breast Surgery, Kameda Medical Center, Kamogawa, Japan.
Masahiro WadaBreast and Thyroid Center, Jyoban Hospital of Tokiwa Foundation, Iwaki, Japan.
Kazunoshin TachibanaBreast and Thyroid Center, Jyoban Hospital of Tokiwa Foundation, Iwaki, Japan.
Tetsuya TanimotoDepartment of Internal Medicine, Navitas Clinic Kawasaki, Kawasaki City, Japan.
Hiroaki ShimmuraDepartment of Urology, Jyoban Hospital of Tokiwa Foundation, Iwaki, Japan.
Tohru OhtakeDepartment of Breast Surgery, Fukushima Medical University, Fukushima, Japan.
Akihiko OzakiBreast and Thyroid Center, Jyoban Hospital of Tokiwa Foundation, Iwaki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Contraceptive counseling for cancer patients, especially during periods of treatment-induced amenorrhea, is often overlooked. This can lead to unexpected pregnancies with significant implications for patient care and outcomes. Case Presentation: We report a case of a 38-year-old BRCA2-positive breast cancer patient who experienced an unexpected twin pregnancy while undergoing treatment with tamoxifen and olaparib. The patient had been amenorrheic since initiating chemotherapy for more than 600 days and had not received contraceptive counseling. The pregnancy was discovered during routine follow-up imaging computed tomography. After thorough counseling regarding the teratogenic potential of her treatments and radiation exposure, and considering the patient's strong desire to prioritize her own treatment to safeguard her existing three children, the pregnancy was terminated. Conclusion: This case highlights the need for comprehensive contraceptive counseling throughout cancer treatment, regardless of apparent fertility status. It also emphasizes the importance of considering both teratogenicity of treatments and patients' personal circumstances in managing unexpected pregnancies in cancer patients.

Indexed as

AmenorrheaBRCA2 proteinBreast neoplasmsContraceptionPregnancyUnplanned pregnancies

Identifiers

PMID40510334
PMCPMC12162116

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.