ArticleChemical science2025
Rh-catalyzed enantioselective hydrosilylation of unactivated alkenes.
Yichen Wu, Hao-Yang Qian, Heng Zhang, Jian-Ye Zou, Qing-Yan Wu, Xiao-Xue Nie, Long Zheng, Qian Peng, Peng Wang
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In one paragraphArticle in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Yichen WuState Key Laboratory of Organometallic Chemistry and Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences CAS 345 Lingling Road Shanghai 200032 P. R. China ywu@sioc.ac.cn pengwang@sioc.ac.cn.
Hao-Yang QianState Key Laboratory of Organometallic Chemistry and Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences CAS 345 Lingling Road Shanghai 200032 P. R. China ywu@sioc.ac.cn pengwang@sioc.ac.cn.
Heng ZhangState Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University Tianjin 300071 P. R. China qpeng@nankai.edu.cn.
Jian-Ye ZouState Key Laboratory of Organometallic Chemistry and Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences CAS 345 Lingling Road Shanghai 200032 P. R. China ywu@sioc.ac.cn pengwang@sioc.ac.cn.
Qing-Yan WuState Key Laboratory of Organometallic Chemistry and Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences CAS 345 Lingling Road Shanghai 200032 P. R. China ywu@sioc.ac.cn pengwang@sioc.ac.cn.
Xiao-Xue NieState Key Laboratory of Organometallic Chemistry and Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences CAS 345 Lingling Road Shanghai 200032 P. R. China ywu@sioc.ac.cn pengwang@sioc.ac.cn.
Long ZhengState Key Laboratory of Organometallic Chemistry and Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences CAS 345 Lingling Road Shanghai 200032 P. R. China ywu@sioc.ac.cn pengwang@sioc.ac.cn.
Qian PengState Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University Tianjin 300071 P. R. China qpeng@nankai.edu.cn.ORCID https://orcid.org/0000-0002-1218-5976 Peng WangState Key Laboratory of Organometallic Chemistry and Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences CAS 345 Lingling Road Shanghai 200032 P. R. China ywu@sioc.ac.cn pengwang@sioc.ac.cn.ORCID https://orcid.org/0000-0002-6442-3008 Funding
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6 · The paper itselfAbstract
Here, we report a highly efficient rhodium-catalysed enantioselective hydrosilylation of unactivated alkenes, achieving excellent regioselectivity and high enantioselectivity. The use of a commercially available chiral ferrocene-based phosphine-oxazoline ligand was crucial in achieving excellent chiral induction and high reactivity with undirected unactiviated alkenes, delivering Si-stereogenic monohydrosilanes in high yields and excellent enantioselectivities. This protocol represents a robust, scalable method for the enantioselective synthesis of Si-stereogenic monohydrosilanes, featuring a low catalyst loading, a broad substrate scope and exceptional functional group and heterocycle tolerance. Moreover, the late-stage functionalization of complex motifs opens a new avenue for incorporating chiral silicon motifs into pharmaceuticals and bioactive compounds.
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PMID40510331
PMCPMC12153506
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