ArticleChemical science2025
Mining peptides for mining solutions: evaluation of calcium-binding peptides for rare earth element separations.
Article in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A family portrait of lanmodulin selectivity for enhanced rare-earth separations.Nature chemical biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Rare earth elements (REEs), which include the 15 lanthanides plus scandium and yttrium, are critical components commonly used in permanent magnets and play a significant role in electronics and green energy technologies. Due to the similarities of these ions, conventional separation processes are chemically- and energy-intensive and generate large quantities of waste. The lanthanides share physical and chemical similarities with calcium ions, which allow REEs to replace calcium in calcium-binding peptides and proteins. In this study, we conducted a bioinformatic search to identify calcium-binding peptides with high affinity to bind and separate REEs. Seven unique domains representing different calcium-binding geometries were selected for evaluation. The results revealed a strong correlation between the charge of the binding loop and its affinity for REEs. We concluded that highly charged, aspartic acid-rich loops exhibit greater electrostatic repulsion, which creates higher affinity due to the increased stabilization effect of ion binding. Binding affinity across the lanthanide series was highest for ions with radii similar to that of calcium (∼1 Å), consistent with the evolutionary optimization of calcium-binding proteins for selective ion recognition. While selectivity varied among proteins in solution, immobilized proteins demonstrated higher selectivity toward intermediate REEs. One notable candidate identified in the bioinformatic search was HEW5 from
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.