Suspected clinical methemoglobinemia associated with administration of hydrogen peroxide 3% in a dog treated for acute ibuprofen ingestion.

Dominique Dominguez, Rebecca Walton

Abstract readCase Reports

In one paragraph

Article in The Canadian veterinary journal = La revue veterinaire canadienne, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dominique DominguezVCA West Los Angeles Animal Hospital, 1900 S. Sepulveda Boulevard, Los Angeles, California 90025, USA (Dominguez, Walton); Department of Veterinary Clinical Sciences, Iowa State University College of Veterinary Medicine, 1800 Christensen Drive, Ames, Iowa 50011, USA (Walton).

Rebecca WaltonVCA West Los Angeles Animal Hospital, 1900 S. Sepulveda Boulevard, Los Angeles, California 90025, USA (Dominguez, Walton); Department of Veterinary Clinical Sciences, Iowa State University College of Veterinary Medicine, 1800 Christensen Drive, Ames, Iowa 50011, USA (Walton).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An 8-month-old intact male golden retriever dog was presented to the emergency department of a large private-practice specialty hospital. The dog had become cyanotic and collapsed following administration (orogastric tube) of 1.4 mL/kg of hydrogen peroxide 3% to induce emesis for ibuprofen ingestion. The dog had severe methemoglobinemia (33%; reference range: 0.3 to 1.5%) and developed anemia. The methemoglobinemia resolved after 24 h of hospitalization with supportive care. Results from assessment with high-performance liquid chromatography/tandem mass spectrometry were consistent with ibuprofen ingestion, with no acetaminophen detected. Key clinical message: This case demonstrated methemoglobinemia in a dog following both ibuprofen ingestion and hydrogen peroxide 3% administration.

Indexed as

Anti-Inflammatory Agents, Non-SteroidalDog DiseasesHydrogen PeroxideIbuprofenMethemoglobinemiaVomitingAnimalsChromatography, High Pressure LiquidDogsMaleTandem Mass SpectrometryAnti-Inflammatory Agents, Non-SteroidalHydrogen PeroxideIbuprofen

Identifiers

PMID40510286

PMCPMC12152687

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.