ArticleFrontiers in cardiovascular medicine2025
Association between serum uric acid to high-density lipoprotein cholesterol ratio (UHR) and abdominal aortic calcification: a cross-sectional study based on NHANES 2013-2014.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Article
- Exploring Uric Acid to HDL Ratio as a Long-Term Biomarker for Diabetes Mellitus.Journal of clinical laboratory analysis · 2026Article
- Association between estimated glucose disposal rate and metabolic dysfunction-associated steatotic liver disease and dyslipidemia in US adults: a cross-sectional study.Frontiers in nutrition · 2025Article
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7 authors.
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Abstract
Background: Cardiovascular diseases (CVDs) are among the leading causes of mortality worldwide, with abdominal aortic calcification (AAC) being an independent risk factor. The serum uric acid (sUA) to high-density lipoprotein cholesterol (HDL-C) ratio (UHR) integrates both pro-atherogenic (sUA-induced endothelial dysfunction) and anti-atherogenic factors (HDL-C-mediated cholesterol efflux), which may be associated with vascular calcification. However, epidemiological evidence on their relationship remains scarce. Methods: This cross-sectional study analyzed data from 2,789 U.S. adults aged ≥40 years in the National Health and Nutrition Examination Survey ( Results: The study included a total of 2,789 participants aged 40 or older. After multifactorial adjustment, the regression model indicated that a higher UHR was significantly associated with increased AAC scores ( Conclusion: In a U.S. middle-aged and elderly population, the UHR was found to be nonlinearly associated with the risk of AAC, and may interact with gender and diabetes. However, due to the cross-sectional design, no causal inferences can be drawn. Future longitudinal studies may be considered to validate these associations and explore whether interventions targeting UHR could potentially slow down the progression of vascular calcification.
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