ArticleBrain, behavior, & immunity - health2025
Physical activity affects DNA methylation-derived inflammation markers in a community-based Parkinson's disease study.
Article in Brain, behavior, & immunity - health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Recreational Exercise and Inflammatory Patterns in Hashimoto's Thyroiditis: Observations from a Cross-Sectional Study.Biomolecules · 2025Observational
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Authors and funding
7 authors.
Funding
Abstract
Introduction: Past studies have connected physical activity (PA) and Parkinson's disease (PD) to chronic inflammation. We use DNA methylation-derived (DNAm) proxies for inflammation to investigate the relationship between PA and chronic inflammation among PD patients. Methods: We collected demographics, lifestyle, and PA status information by interviewing 555 PD patients enrolled in the Parkinson's Environment and Gene (PEG) studies. We used the epigenetic clock website to generate DNAm proxies and performed principal component analysis (PCA) of 22 DNAm cytokine proxies. Using the Mann-Whitney Results: Compared to sedentary PD patients, those who reported strenuous PA have lower levels of c-reactive protein (CRP; p < 0.01) and higher levels of Fc receptor-like 2 (FcRL2; p = 0.02). Patients who engaged in moderate PA have lower levels of C-X-C motif chemokine ligand 9 (CXCL9; p = 0.03), 10 (CXCL10; p = 0.02), and 11 (CXCL11; p = 0.01). Among active patients, strenuous PA is non-linearly (convex-shape) associated with the proportions of natural killer cells (NK; p = 0.02) and CD8T cells (p = 0.05) and negatively associated with CRP levels (p = 0.02). We also observe a non-linear association between moderate PA and monocyte counts (p = 0.02). Conclusion: PA may benefit PD patients by reducing chronic inflammation. We also found that strenuous PA may increase the proportions of NK and CD8T cells, though further effort is needed to confirm potential shifts in immune cell subtypes.
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