ReviewFrontiers in plant science2025
Unlocking the potential of flavonoid biosynthesis through integrated metabolic engineering.
Review in Frontiers in plant science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Integrated Transcriptomic, Enzymatic, and Immunolocalization Analysis Reveals Pectin Remodeling-Mediated Defense AgainstCurrent issues in molecular biology · 2026Article
- Integration of Transcriptomics and Metabolomics Reveals Organ-Specific Biosynthesis and Accumulation of Pharmacologically Active Flavonoids inPlants (Basel, Switzerland) · 2026Article
- Sphingomonas incarnata sp. nov., an endophytic bacterium with bioactive potential isolated from passionfruit leaves.BMC microbiology · 2026Article
- Evolutionary Characteristics and Expression Patterns of theCurrent issues in molecular biology · 2026Article
- Integrative structural and physicochemical characterization of chalcone synthase enzymes from medicinal plants using AlphaFold, molecular docking, and molecular dynamics.Scientific reports · 2026Article
- AI-driven multiscale virtual plant cell modeling: from molecular mechanisms to tissue functions.Planta · 2026Review
- Tailored UV-A Irradiation and Callus Selection Enable Distinct Flavonoid Profile Production in Grape Cell Cultures.Foods (Basel, Switzerland) · 2026Article
- Oral whole-leaf matcha partially attenuates UV-induced dermoepidermal disruption and collagen phenotype alterations in a rat model of repeated photoaging.Frontiers in medicine · 2026Article
- Microbial consortia and their metabolic modulations as mechanisms of water deficit tolerance in strawberry plants.Frontiers in plant science · 2026Article
- Responses and adaptations of plants to abiotic stress: transcriptional regulation of secondary metabolic pathways, metabolomics, and nanobiological approaches.Frontiers in genetics · 2026Review
- Exploring Microbiome-based Therapy: Bacterial Flavonoid Synthesis as a Novel Approach to PCOS Treatment.Current drug metabolism · 2026Review
- Integrated metabolomic and transcriptomic analysis of the mechanism underlying leaf variegation inFrontiers in plant science · 2026Article
- Environmental control of anthraquinone-flavonoid accumulation in wild plant species: biosynthetic pathways, ecological drivers, and adaptive significance.Frontiers in plant science · 2026Review
- A review of flavonoids at the crossroads of plant defense: integrating biotic and abiotic stress tolerance through AI- and CRISPR/Cas-guided metabolic reprogramming.Frontiers in plant science · 2026Review
- Characterization of two reductasesFrontiers in plant science · 2025Article
- The pharmacological effects and therapeutic potential of flavonoids in digestive diseases.Frontiers in pharmacology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flavonoids are a diverse class of plant polyphenols with essential roles in development, defense, and environmental adaptation, as well as significant applications in medicine, nutrition, and cosmetics. However, their naturally low abundance in plant tissues poses a major barrier to large-scale utilization. This review provides a comprehensive and forward-looking synthesis of flavonoid biosynthesis, regulation, transport, and yield enhancement strategies. We highlight key advances in understanding transcriptional and epigenetic control of flavonoid pathways, focusing on the roles of MYB, bHLH, and WD40 transcription factors and chromatin modifications. We also examine flavonoid transport mechanisms at cellular and tissue levels, supported by emerging spatial metabolomics data. Distinct from conventional reviews, this review explores how plant cell factories, genome editing, environmental optimization, and artificial intelligence (AI)-driven metabolic engineering can be integrated to boost flavonoid production. By bridging foundational plant science with synthetic biology and digital tools, this review outlines a novel roadmap for sustainable, high-yield flavonoid production with broad relevance to both research and industry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.