ArticleFrontiers in oncology2025
Genomic profiles and prognostic biomarkers of resectable lung adenocarcinoma with a micropapillary component.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Effects of the Pharmacological Modulation of NRF2 in Cancer Progression.Medicina (Kaunas, Lithuania) · 2025Review
- Molecular features influencing clinical outcome of advanced HER2-positive gastric cancer receiving trastuzumab plus chemotherapy.Annals of medicine · 2025Article
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11 authors.
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Abstract
Background: Lung adenocarcinoma with a micropapillary component (LMPC) is an aggressive histologic subtype of lung cancer characterized by unique pathological features and poor prognosis. While previous studies have identified driver mutations in LMPC, its comprehensive molecular profile and prognosis-related biomarkers in the Chinese population remain poorly understood. Methods: We conducted a retrospective study of 54 stage I-III LMPC patients who underwent complete resection. Tumor samples from these patients were analyzed using broad-panel next-generation sequencing of 425 cancer-related genes. We explored the associations among clinicopathologic factors, genomic characteristics, and post-operative recurrence risk. Results: Compared to a reference cohort of 113 LADC patients, LMPC exhibited a distinct genetic profile, with a greater diversity of targetable mutations, an increased number of oncogenic pathway alterations (NPA), and more oncogenic pathway-related alterations. The mutation frequencies of Conclusion: Our study elucidates the unique genetic landscape of Chinese resectable LMPC patients and highlights high TMB and mutations in
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