ArticleiScience2025
Global analysis of excitotoxicity-induced alterations in RNA structure and RNA-protein binding in neurons.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
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Authors and funding
8 authors.
Funding
Abstract
Excitotoxicity and altered RNA regulation by RNA-binding proteins (RBPs) are two prevalent hallmarks in multiple neurodegenerative disorders. However, global effects of excitotoxicity on RNA secondary structure and RNA-protein interactions are largely unknown. To address this, we have performed protein interaction profile sequencing (PIP-seq) in NMDA-treated primary neurons. Our results show that NMDA treatment alters RNA structure, which correlates, in opposite directions depending on the intragenic region, with changes in mRNA abundance. Moreover, NMDA treatment increases and alters RNA-protein binding sites defining subsets of transcripts functionally associated with synaptic functions and neurodegenerative disorders. Finally, we identify two RNA motifs enriched in protein binding after NMDA treatment, and several RBPs binding to them
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Registered trials
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