Evidence map›Paper›PMID 40510129›Full record

ArticleiScience2025

Macrophages with different origins proliferate

Sara A Habash, Naofumi Takahashi, Youssef M Eltalkhawy, Randa A Abdelnaser, Hiromi Ogata-Aoki, Seiji Okada, Hitoshi Takizawa, Shingo Usuki, Kan Etoh, Shinjiro Hino and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Human peritoneal CCR2Human cell · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sara A HabashDivision of Infection & Hematopoiesis, Kumamoto University, Kumamoto, Japan.
Naofumi TakahashiDivision of Infection & Hematopoiesis, Kumamoto University, Kumamoto, Japan.
Youssef M EltalkhawyDivision of Infection & Hematopoiesis, Kumamoto University, Kumamoto, Japan.
Randa A AbdelnaserDivision of Infection & Hematopoiesis, Kumamoto University, Kumamoto, Japan.
Hiromi Ogata-AokiDivision of Hematopoiesis, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
Seiji OkadaDivision of Hematopoiesis, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
Hitoshi TakizawaLaboratory of Stem Cell Stress, International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan.
Shingo UsukiLiaison Laboratory Research Promotion Center, Kumamoto University, Kumamoto, Japan.
Kan EtohDepartment of Medical Cell Biology, Kumamoto University, Kumamoto, Japan.
Shinjiro HinoDepartment of Medical Cell Biology, Kumamoto University, Kumamoto, Japan.
Saori Morino-KogaDepartment of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.
Minetaro OgawaDepartment of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.
Shinya SuzuDivision of Infection & Hematopoiesis, Kumamoto University, Kumamoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages are maintained by bone marrow (BM)-derived monocytes, but macrophages originating from fetal liver (FL) or yolk sac (YS) persist in many adult tissues due to their higher proliferative capacity. Here, we report useful models of macrophages with different origins. We expanded macrophages from mouse BM, FL, or YS through long-term culture. They proliferated with M-CSF, and YS lines were the fastest and survived without M-CSF for a longer period. YS and FL lines were more resistant to apoptotic cell death and similar in gene expression/chromatin accessibility, whereas YS and BM lines exhibited the most distinct profiles. When transplanted into mice, YS line expressed markers lost during the culture. BM, FL, and YS lines appear to maintain differences in intrinsic proliferation/anti-apoptosis/survival capacities and can restore phenotypes lost during the culture by

Indexed as

Biological sciencesComponents of the immune systemImmunology

Identifiers

PMID40510129
PMCPMC12159446

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.