ArticleiScience2025
All active hippocampal pyramidal cells are place cells.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Overlapping representations in the ventral hippocampus support rapid fear memory retrieval.Nature neuroscience · 2026Article
- Rapid formation of non-spatial hippocampal representations consistent with behavioral timescale synaptic plasticity is modulated by entorhinal input.Nature communications · 2026Article
- The Map's Design: Evolution's Impact on Navigation and Spatial Cognition.Animals : an open access journal from MDPI · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hippocampal place cells - neurons whose activity is modulated by spatial position - are considered an essential substrate of spatial cognition. Despite decades of research, the fraction of hippocampal place cells remains debated, with studies reporting between 20% and 90% of the recorded populations. This raises the question of whether distinct subsets of cells - place cells and non-place cells - genuinely exist in the hippocampus. Here, we developed an analytical approach that estimates place cells' fraction by fitting measured neuronal activity to simulated datasets with different fractions of place cells. We found that in familiar environments, all neurons recorded from the mouse dorsal CA1 are place cells. In novel environments, place cells' fraction is lower, yet many cells naively classified as non-place cells are in fact modulated by position, but their fields are unstable. Overall, our findings suggest there are no distinct subsets but rather that all active cells are spatially informative.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.