Evidence map›Paper›PMID 40510123›Full record

ArticleiScience2025

Reduced nephrin tyrosine phosphorylation impairs podocyte force transmission and accelerates detachment in disease.

Casey R Williamson, Claire E Martin, J Dinesh Kumar, Peihua Lu, Laura A New, Alice Y Wang, Nils M Kronenberg, Malte C Gather, Paul A Reynolds, Nina Jones

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Casey R WilliamsonDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Claire E MartinDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada.
J Dinesh KumarSUPA, School of Physics and Astronomy, University of St. Andrews, KY16 9SS St. Andrews, UK.
Peihua LuDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Laura A NewDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Alice Y WangDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Nils M KronenbergSUPA, School of Physics and Astronomy, University of St. Andrews, KY16 9SS St. Andrews, UK.
Malte C GatherSUPA, School of Physics and Astronomy, University of St. Andrews, KY16 9SS St. Andrews, UK.
Paul A ReynoldsBiomedical Sciences Research Complex, University of St. Andrews, KY16 9ST St. Andrews, UK.
Nina JonesDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Podocytes are specialized kidney cells that form the slit diaphragm (SD), an intercellular filtration barrier against plasma protein loss. The SD is subject to significant mechanical strain which can be amplified in disease, leading to podocyte detachment. One key SD protein that might intercept mechanical strain and transmit adhesion signals is nephrin, although its influence on podocyte force transmission remains uncharacterized. Using immunoblotting and elastic resonator interference stress microscopy (ERISM), we demonstrate that nephrin clustering induces rapid podocyte force transmission and adhesion protein activation (paxillin, FAK, and p130Cas), which require nephrin tyrosine phosphorylation at its three YDxV motifs. Furthermore, using a model of diabetic nephropathy to amplify mechanical stress

Indexed as

BiochemistryBiomechanicsCell biologySpecialized functions of cells

Identifiers

PMID40510123
PMCPMC12159891

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.