Evidence map›Paper›PMID 40510118›Full record

ArticleiScience2025

Nickel-catalyzed domino annulation coupling to construct oxindole analogues: A mechanistic and synthetic investigation.

Hui Chen, Zhenkang Ai, Siyuan Jin, Bei Zhang, Yaopeng Li, Xuebin Liao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hui ChenSchool of Pharmaceutical Sciences, State Key Laboratory of Molecular Oncology, Tsinghua-Peking Center for Life Science, Tsinghua University, Beijing 100084, China.
Zhenkang AiSchool of Pharmaceutical Sciences, State Key Laboratory of Molecular Oncology, Tsinghua-Peking Center for Life Science, Tsinghua University, Beijing 100084, China.
Siyuan JinSchool of Pharmaceutical Sciences, State Key Laboratory of Molecular Oncology, Tsinghua-Peking Center for Life Science, Tsinghua University, Beijing 100084, China.
Bei ZhangSchool of Chemistry and Materials Science, Institute of Advanced Materials and Flexible Electronics (IAMFE), Nanjing University of Information Science and Technology, Nanjing 210044, China.
Yaopeng LiSchool of Pharmaceutical Sciences, State Key Laboratory of Molecular Oncology, Tsinghua-Peking Center for Life Science, Tsinghua University, Beijing 100084, China.
Xuebin LiaoSchool of Pharmaceutical Sciences, State Key Laboratory of Molecular Oncology, Tsinghua-Peking Center for Life Science, Tsinghua University, Beijing 100084, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nickel-catalyzed reductive coupling reactions are widely used to construct molecular scaffolds; however, the mechanisms of these reactions remain less studied. Here, we present a nickel-catalyzed reductive cyclization method to construct oxindole bearing new formed C-X (X = CN, I, and P) bonds. To investigate the detailed mechanism, different types of ligand-chelated σ-alkyl-Ni(II) complexes were isolated, characterized, and allowed to conduct relevant stoichiometric and catalytic reactions. Our collected data indicated that

Indexed as

ChemistryOrganic chemistry

Identifiers

PMID40510118
PMCPMC12159493

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.