ArticleCureus2025
Comparison of Seven-Day Versus Continuous Prophylactic Antibiotic Therapy Until Delivery in Preterm Premature Rupture of Membranes.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Agent, Dose and Duration: The Unanswered Questions Behind Latency Antibiotic Therapy for Preterm Prelabour Rupture of Membranes.Antibiotics (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aim Preterm prelabour rupture of membranes (PPROM) refers to the spontaneous rupture of fetal membranes before the onset of labor and prior to 37 completed weeks of gestation. PPROM is associated with significant maternal and neonatal complications. Maternal risks include chorioamnionitis, abruptio placentae, and postpartum infections. Neonatal complications commonly observed are respiratory distress syndrome (RDS), neonatal sepsis, cerebral palsy, and necrotizing enterocolitis (NEC). This study aimed to evaluate and compare maternal and neonatal outcomes in women with PPROM treated with prophylactic antibiotics for seven days versus antibiotics administered until delivery. Materials and methods This comparative study included 110 pregnant women between 26 weeks 0 days and 36 weeks six days of gestation. Participants were divided into the following two groups: group 1 received prophylactic antibiotics for seven days, and group 2 received antibiotics until delivery. Data collected included the duration of membrane rupture, types of antibiotics used, and various maternal and neonatal outcomes. Results A significantly lower incidence of persistent amniotic fluid leakage was observed in group 1 (31; 56.4%) compared to group 2 (45; 81.8%) (p<0.002). Continuous positive airway pressure (CPAP) support was not required in 41 (74.5%) of neonates in group 1 and 40 (72.7%) in group 2. However, a significantly higher proportion of neonates in group 2 required high-flow nasal cannula (HFNC) support compared to group 1 (p=0.015). Additionally, a shorter neonatal hospital stay (one to three days) was more frequent in group 1 (29; 52.7%) than in group 2 (17; 30.9%) (p=0.048). Conclusion A seven-day course of prophylactic antibiotics in PPROM is as effective as continuous antibiotic therapy until delivery, with added benefits of reduced neonatal hospital stay and potentially fewer antibiotic-associated risks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.