ArticleCureus2025
Local Ablative Treatment of the Primary Tumour in Patients With Metastatic Breast Cancer: A Retrospective Observational Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
backgroundMetastatic disease is the cause of death in most patients with breast cancer. The potential benefits of breast surgery (i.e., mastectomy or lumpectomy) of the primary tumour in patients with metastatic breast cancer are controversial. In clinical practice, selected multimetastatic and oligometastatic patients who show a complete metabolic response to systemic treatment receive local ablative treatment (breast surgery and/or radiotherapy) of their primary tumour.
objectivesWe described the local ablative treatment of primary tumours received by patients with oligometastatic and multimetastatic breast cancer with good systemic treatment response and analysed our cohort's progression-free survival (PFS). PATIENTS AND
methodsA retrospective, descriptive cohort study was conducted at the Consorci Sanitari de Terrassa, Spain, from March 2013 to November 2023. We included all consecutive patients aged ≥18 years with histologically confirmed metastatic breast cancer who underwent local ablative treatment after receiving systemic therapy. Oligometastatic patients presented with up to five metastatic lesions.
resultsSeventeen patients were included in our study, 16 females and one male, with a median age of 50 years (range: 26-72). Most had luminal breast cancer (9, 53%) and were classified as oligometastatic (12, 71%). Their systemic treatments followed international guidelines for each molecular subtype. The most frequently performed local ablative treatment was mastectomy with axillary lymphadenectomy (7, 41%); eight patients (47%) received local ablative treatment (radiotherapy) for metastatic lesions. The median PFS from the date of diagnosis was not reached; at 60 months, the probability of not relapsing was 92%. The median PFS from the date of local ablative treatment was also not reached; at 60 months, the probability of not relapsing was 78%.
conclusionsIn this small local series, patients with oligometastatic or multimetastatic breast cancer achieving a good response to systemic therapy and receiving local ablative treatment of their primary tumour showed excellent PFS from the date of diagnosis and from the date of local ablative treatment.
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