ArticleCureus2025
Temporal Trends and Disparities in Chronic Liver Disease Mortality: An Analysis Using National Center for Health Statistics (NCHS) Data Ranging From 1999 to 2023.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Portal hypertension mortality in the United States (1999-2023): Insights from the CDC WONDER database.Medicine · 2026Article
- Demographic profiles and disparities in all liver diseases and diabetes mellitus patients - related mortality among older adults (≥ 65) in the United States, 1999 to 2020.BMC gastroenterology · 2026Article
- Dissecting incidence and mortality inequalities of six types of liver diseases in 39 alcohol-dominant countries and 93 virus-dominant countries under the aging context: Insights from the Global Burden of Disease Study 2021.Translational oncology · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic liver disease (CLD) remains a significant global health concern, with fluctuating mortality trends over the past two decades. This study analyzes age-adjusted CLD mortality rates using data from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) from 1999 to 2023, highlighting temporal trends and demographic disparities.
methodsWe conducted a retrospective analysis of CLD mortality rates stratified by year, gender, race, age group, and Hispanicity. Age-adjusted mortality rates were computed using direct standardization, and trends were examined over different periods.
resultsBetween 1999 and 2006, CLD mortality rates declined from 9.6 to 8.8 per 100,000 population. However, from 2007 onward, mortality rates increased, peaking at 14.5 in 2021, largely driven by the COVID-19 pandemic. Males exhibited consistently higher mortality rates than females. Racial disparities were evident, with American Indian/Alaska Native populations experiencing the highest mortality rates. Age-related trends showed the greatest burden in older adults, while mortality rates in younger populations also rose in recent years. Hispanic individuals demonstrated a significant increase in CLD mortality, particularly post-2010.
conclusionCLD mortality has risen significantly since 2007, with a pronounced peak in 2021. Despite a post-pandemic decline, rates remain above pre-2019 levels. These findings emphasize the significance of customized public health interventions and strategies tackling alcohol use, various metabolic risk factors, and healthcare access, especially for high-risk individuals and populations.
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