Evidence map›Paper›PMID 40510030›Full record

ArticleCancer drug resistance (Alhambra, Calif.)2025

FGFR1 overexpression promotes resistance to PI3K inhibitor alpelisib in luminal breast cancer cells through receptor tyrosine kinase signaling-mediated activation of the estrogen receptor.

Yujie Shi, Lexia Chen, Qiong Cheng, Peijia Niu, Yahan Weng, Xiaohe Yang

Abstract read
In one paragraph

Article in Cancer drug resistance (Alhambra, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Translational cancer research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yujie ShiDepartment of Pathology, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan, China.
Lexia ChenDepartment of Pathology, Fuwai Central China Cardiovascular Hospital, Zhengzhou 450003, Henan, China.
Qiong ChengDepartment of Pathology, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan, China.
Peijia NiuDepartment of Pathology, Fuwai Central China Cardiovascular Hospital, Zhengzhou 450003, Henan, China.
Yahan WengDepartment of Pathology, Fuwai Central China Cardiovascular Hospital, Zhengzhou 450003, Henan, China.
Xiaohe YangDepartment of Biological and Biomedical Sciences, Biomedical/Biotechnology Research Institute, North Carolina Research Campus, North Carolina Central University, Kannapolis, NC 28081, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

alpelisibAZD4547estrogen receptorFGFR1fulvestrantPI3Kresistance

Identifiers

PMID40510030
PMCPMC12159599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.