ArticleThe Journal of infectious diseases2025
Serosurveillance Identifies an Endemic Hotspot of Lassa Fever in Faranah, Upper Guinea.
Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Climate-driven host ecology as a framework for zoonotic disease risk: Understanding transferability across arenavirus systems.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Strengthening diagnostic capacity for viral hemorrhagic fevers in Forest Guinea: advances in Lassa fever case detection.Npj viruses · 2026Article
- Lassa Virus-A Persistent and Evolving Threat.Microorganisms · 2026Review
- Nosocomial Outbreak of Lassa Fever in Conakry, Guinea, 2022.The Journal of infectious diseases · 2026Article
- Evaluating vectors for the design of a spillover-disrupting Lassa virus transmissible vaccine.PLoS computational biology · 2026Article
- Genomic Surveillance of Lassa Virus through In-Country Sequencing, Guinea.Emerging infectious diseases · 2026Article
- Local heterogeneity in Lassa fever serology in rural Nigeria: Implications for vaccine trial site selection.PLoS neglected tropical diseases · 2026Article
- Sero-genomic evidence for occult mpox exposure in healthy Nigerian adults.Nature communications · 2026Article
- Screening of the Pandemic Response Box Library Identified CRM1/XPO1 as an Anti-Mammarenavirus Druggable Target.Viruses · 2026Article
- A One Health trial design to accelerate Lassa fever vaccines.Nature medicine · 2026Article
- Genomic epidemiology and evolutionary analysis of Lassa virus from small mammals suggest bidirectional viral movement across humans and animals.Virus evolution · 2026Article
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Authors and funding
12 authors.
Funding
Abstract
backgroundLassa fever, caused by Lassa virus (LASV), is a rodent-borne disease endemic to West Africa. Despite growing interest from the global health community, the overall disease burden remains poorly understood due to persistent underreporting and inadequate diagnostic capacities. This study aimed to assess LASV infection dynamics in rural Guinea, addressing gaps in understanding its epidemiology in endemic settings.
methodsA cross-sectional serosurveillance study was conducted across 6 villages in Faranah, Guinea, involving 1306 participants. Serum samples were analyzed for LASV-specific antibodies using enzyme-linked immunosorbent assay, and a subset confirmed via immunofluorescence and neutralization assays. Statistical and mathematical models were used to estimate key epidemiological parameters, including the force of infection, antibody waning rates, and infection prevalence.
resultsOverall, IgG seroprevalence was 82.3%, while IgM prevalence stood at 1.8%. Seroprevalence of IgG exceeded 50% by age 5 and increased steadily with age, indicating lifelong exposure. Antibody waning rates suggested an average IgG persistence of 58 years. Mathematical analysis showed that halving LASV prevalence would require a 10-fold reduction in the force of spillover, highlighting the challenges of effective control measures.
conclusionsThe seroprevalence observed in this study was markedly higher than reported elsewhere in West Africa, identifying Faranah as a hotspot for LASV transmission. Despite the high seroprevalence and estimated force of infection, the number of reported acute cases is very low, suggesting that LASV may frequently cause pauci- or asymptomatic infections or be commonly misdiagnosed for other diseases. These findings underscore that LASV is more widespread than assumed in rural Guinea.
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