Evidence map›Paper›PMID 40509996›Full record

ArticleCirculation. Genomic and precision medicine2025

Plasma Proteomics Reveals Dysregulated Pathways Across the Spectrum

Usman A Tahir, Daniel Reichart, Anisha Purohit, Jacob L Barber, Gaurav Tiwari, Laurie Farrell, Julia E Marine, Darius Roy, Joshen Patel, Catherine G Ireland and 4 more

Abstract read
In one paragraph

Article in Circulation. Genomic and precision medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Usman A TahirDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (U.A.T., J.L.B., G.T., L.F.).ORCID 0000-0002-3657-6082
Daniel ReichartHarvard Medical School, Boston, MA (U.A.T., D. Reichart, C.G.I., C.Y.H., C.E.S., R.E.G., N.K.L.).
Anisha PurohitDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (D. Reichart, A.P., J.E.M., D. Roy, J.P., C.G.I., C.Y.H., C.E.S., R.E.G., N.K.L.).ORCID 0000-0002-8029-8358
Jacob L BarberDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (U.A.T., J.L.B., G.T., L.F.).
Gaurav TiwariDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (U.A.T., J.L.B., G.T., L.F.).ORCID 0009-0000-2540-6005
Laurie FarrellDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (U.A.T., J.L.B., G.T., L.F.).ORCID 0000-0002-5717-527X
Julia E MarineDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (D. Reichart, A.P., J.E.M., D. Roy, J.P., C.G.I., C.Y.H., C.E.S., R.E.G., N.K.L.).ORCID 0009-0009-0380-9263
Darius RoyDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (D. Reichart, A.P., J.E.M., D. Roy, J.P., C.G.I., C.Y.H., C.E.S., R.E.G., N.K.L.).ORCID 0009-0004-0978-1664
Joshen PatelDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (D. Reichart, A.P., J.E.M., D. Roy, J.P., C.G.I., C.Y.H., C.E.S., R.E.G., N.K.L.).ORCID 0000-0001-5086-2002
Catherine G IrelandHarvard Medical School, Boston, MA (U.A.T., D. Reichart, C.G.I., C.Y.H., C.E.S., R.E.G., N.K.L.).
Carolyn Y HoHarvard Medical School, Boston, MA (U.A.T., D. Reichart, C.G.I., C.Y.H., C.E.S., R.E.G., N.K.L.).ORCID 0000-0002-7334-7924
Christine E SeidmanHarvard Medical School, Boston, MA (U.A.T., D. Reichart, C.G.I., C.Y.H., C.E.S., R.E.G., N.K.L.).ORCID 0000-0001-6380-1209
Robert E GersztenHarvard Medical School, Boston, MA (U.A.T., D. Reichart, C.G.I., C.Y.H., C.E.S., R.E.G., N.K.L.).ORCID 0000-0002-6767-7687
Neal K LakdawalaHarvard Medical School, Boston, MA (U.A.T., D. Reichart, C.G.I., C.Y.H., C.E.S., R.E.G., N.K.L.).ORCID 0000-0001-6458-5421

Funding

The Role of SECTM1 in Monocyte Biology and AtherosclerosisK08HL161445 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Usman A. Tahir · 2022 to 2026
$822k
NHLBI NIH HHS K08 HL161445
6 · The paper itself

Abstract

backgroundPathogenic variants in the

methodsTo identify proteins and biological pathways associated with likely pathogenic/pathogenic

resultsWe identified several novel proteins associated with

conclusionsProteomic profiling in individuals with likely pathogenic/pathogenic

Indexed as

Cardiomyopathy, DilatedLamin Type AProteomicsAdultFemaleHumansMaleMiddle AgedLamin Type ALMNA protein, humanbiomarkerscardiomyopathy, dilatedlamin type Aprincipal component analysisproteomics

Identifiers

PMID40509996
PMCPMC12313287

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.