ArticleTropical medicine & international health : TM & IH2025
Lymphopenia: An early indicator of Crimean-Congo haemorrhagic fever.
Article in Tropical medicine & international health : TM & IH, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Diagnostic performance of clinical symptom combinations for Crimean-Congo hemorrhagic fever in emergency department patients with reported arthropod bites, stings, or exposure.Tropical medicine and health · 2026Article
- Venturing into host-pathogen interaction in Crimean-Congo hemorrhagic fever to highlight terra incognita.Frontiers in immunology · 2026Review
- Lymphopenia: An early indicator of Crimean-Congo haemorrhagic fever.Tropical medicine & international health : TM & IH · 2025Article
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2 authors.
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Abstract
objectivesCrimean-Congo haemorrhagic fever is a lethal tick-borne disease characterised by initially nonspecific symptoms. While thrombocytopenia and leucopenia are established diagnostic markers, there is a need for earlier indicators. This study evaluates lymphopenia as a marker for Crimean-Congo haemorrhagic fever.
methodsThis retrospective study analysed patients admitted with arthropod bites from 2018 to 2021. Patients were classified based on initial leucocyte and platelet counts into Group 1 (normal values) and Group 2 (low values). Within Group 1, patients were classified as Group 1B if they developed thrombocytopenia and leucopenia during follow-up, whereas those with stable counts were designated as Group 1A. Variance and ROC curve analysis were used to evaluate blood counts.
resultsOf 914 evaluated patients, 870 with normal CBCs were categorised into Group 1, and 44 with low counts into Group 2. Within Group 1, 16 patients subsequently developed thrombocytopenia and leucopenia (Group 1B), while the rest remained stable (Group 1A). All patients in Groups 1B and 2 were later confirmed to have Crimean-Congo haemorrhagic fever via RT-PCR. Initial lymphocyte counts varied significantly, with 2.7 × 10
conclusionsLymphocyte depletion precedes changes in leucocyte and platelet counts, affirming its potential as an early diagnostic marker for Crimean-Congo haemorrhagic fever. Early detection through lymphocyte monitoring could improve patient management and reduce transmission in endemic areas.
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