Evidence map›Paper›PMID 40509886›Full record

ReviewLab on a chip2025

Patient-derived organotypic tumor spheroids, tumoroids, and organoids: advancing immunotherapy using state-of-the-art 3D tumor model systems.

David J Bozym, David X Zheng, Or-Yam Revach, Amir Aref, Russell W Jenkins

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Lab on a chip, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Leveraging Microphysiological Systems to Facilitate Neutrophil-Based Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

David J BozymMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St., Jackson 904B, Boston, MA 02114, USA. rjenkins@mgh.harvard.edu.
David X ZhengMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St., Jackson 904B, Boston, MA 02114, USA. rjenkins@mgh.harvard.edu.
Or-Yam RevachMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St., Jackson 904B, Boston, MA 02114, USA. rjenkins@mgh.harvard.edu.
Amir ArefBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Russell W JenkinsMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St., Jackson 904B, Boston, MA 02114, USA. rjenkins@mgh.harvard.edu.ORCID 0000-0001-6110-2148

Funding

Pathways to Mentorship and Research: Training the Next Generation Physician-ScientistsR25AI147393 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2019 to 2024
$1.8M
MGH Diseases of Aging Pathway Via Stimulating Access to Research in Residency (MGH DAP StARR)R38AG070229 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI BRADLEY T. HYMAN, Christine S Ritchie · 2023 to 2026
$1.1M
NIAID NIH HHS R25 AI147393NIA NIH HHS R38 AG070229
6 · The paper itself

Abstract

Preclinical

Indexed as

ImmunotherapyNeoplasmsOrganoidsSpheroids, CellularHumansLab-On-A-Chip DevicesTumor Microenvironment

Identifiers

PMID40509886
PMCPMC12227171

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.