Evidence map›Paper›PMID 40509835›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2025

[Dynamic distribution and clearance of

J Zou, T Gao, Y Wang, M Ren, D Liu, R Long, Y Cheng, M Liu, Z Xu, Z Xie and 3 more

Abstract readEnglish Abstract
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

J ZouInstitute of Medical Technology, Peking University Health Science Center, Beijing 100191, China.
T GaoInstitute of Medical Technology, Peking University Health Science Center, Beijing 100191, China.
Y WangInstitute of Medical Technology, Peking University Health Science Center, Beijing 100191, China.
M RenInstitute of Medical Technology, Peking University Health Science Center, Beijing 100191, China.
D LiuPeking University Third Hospital Drug Clinical Trial Institute, Beijing 100191, China.
R LongInstitute of Medical Technology, Peking University Health Science Center, Beijing 100191, China.
Y ChengInstitute of Medical Technology, Peking University Health Science Center, Beijing 100191, China.
M LiuDepartment of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China.
Z XuDepartment of Natural Medicines, Peking University School of Pharmaceutical Sciences, Beijing 100191, China.
Z XieInstitute of Medical Technology, Peking University Health Science Center, Beijing 100191, China.
P LvDepartment of Mechanics and Engineering Science, Peking University School of Engineering, Beijing 100871, China.
L YuanInstitute of Medical Technology, Peking University Health Science Center, Beijing 100191, China.
H HanInstitute of Medical Technology, Peking University Health Science Center, Beijing 100191, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the distribution and clearance of

methodsAfter the injection of a volume of 2 μL and radioactive activity of about 3.7 MBq (100 μCi) of

resultsSPECT/CT imaging results showed that after

conclusionIntracerebral ECS administration is a promising method of administration, but there are significant differences in distribution and clearance in different brain regions. This study further expands the content and significance of "ECS regions", and also provides an important theoretical foundation for the treatment of encephalopathy and the research of new drugs through brain ECS in the future.

Indexed as

BrainExtracellular SpaceRadiopharmaceuticalsTechnetium Tc 99m PentetateAnimalsMaleRatsRats, Sprague-DawleySingle Photon Emission Computed Tomography Computed TomographyTissue DistributionTomography, Emission-Computed, Single-PhotonRadiopharmaceuticalsTechnetium Tc 99m Pentetate99mTc-DTPABrainExtracellular spaceInterstitial fluidTissue distribution

Identifiers

PMID40509835
PMCPMC12171589

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.