Evidence map›Paper›PMID 40509826›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2025

[Associations of metabolic dysfunction-associated steatotic liver disease and cardiometabolic risk factor abnormalities with adverse pregnancy outcomes].

S Yang, Y Li, H Cui, Y Wang, Y Wu, M Wang, Y Yang, N Enkar, L Yang, H Wang

Abstract readEnglish Abstract

In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

S YangDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China.

Y LiDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.

H CuiDepartment of Global Health, School of Public Health, Peking University, Beijing 100191, China.

Y WangDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China.

Y WuDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China.

M WangDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China.

Y YangDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China.

N EnkarDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China.

L YangDepartment of Obstetrics and Gynecology, Beijing Friendship Hospital, Capital University of Medical Sciences, Beijing 100050, China.

H WangDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the association between metabolic dysfunction-associated steatotic liver disease (MASLD) and the risk of adverse pregnancy outcomes, and to analyze the impact of the type and severity of cardiometabolic risk factor (CMRF) abnormalities on this association.

methodsA retrospective cohort study was conducted among primiparous women with singleton pregnancies who had registered at Beijing Friendship Hospital from March 10, 2020, to December 31, 2022. A total of 2 623 women were included. Basic characteristics and delivery outcomes were documented, liver ultrasound and relevant prenatal examinations were performed, and adverse pregnancy outcomes were diagnosed. Modified Poisson regression models were used to analyze the association between MASLD and adverse pregnancy outcomes. The relationship between the type or severity of CMRF abnormalities in MASLD and the risk of adverse pregnancy outcomes was also explored.

resultsAfter adjusting for confounding factors including age, gestational weight gain, and education level, MASLD was associated with an increased risk of cesarean section (

conclusionMASLD during pregnancy is associated with an increased risk of multiple adverse pregnancy outcomes, and the type and severity of CMRF abnormalities significantly influence this association. These results suggest that attention should be paid to the specific CMRF abnormalities when diagnosed MASLD, as this may help to facilitate targeted interventions and reduce the risk of adverse pregnancy outcomes.

Indexed as

Cardiometabolic Risk FactorsFatty LiverPregnancy ComplicationsPregnancy OutcomeAdultCesarean SectionDiabetes, GestationalFemaleHumansPregnancyPremature BirthRetrospective StudiesRisk FactorsAdverse pregnancy outcomeCardiometabolic risk factorLiver diseaseMetabolic dysfunction-associated steatotic liver diseasePregnancy outcome

Identifiers

PMID40509826

PMCPMC12171599

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.