ArticleAnnals of clinical and translational neurology2025
Stage-Dependent Inhibitory Connectivity in Striatal-Motor Circuit in Huntington's Disease.
Article in Annals of clinical and translational neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElucidating dysfunctional connectivity patterns among key brain regions in Huntington's disease (HD) underlying progression may have implications for developing treatment and therapeutic evaluation.
objectiveExplore the relationship between abnormal spontaneous resting-state activity and atrophy in HD-specific brain regions and clarify effective connectivity changes among them across different stages of HD.
methodsAmplitude of low-frequency fluctuation (ALFF) analysis was used to detect abnormal spontaneous neural activity; voxel-based morphometry analysis was applied to assess atrophy; spectral dynamic causal model (DCM) was conducted to estimate regional effective connectivity between HD participants and healthy controls, as well as between preclinical mutation carriers and symptomatic patients.
resultsVoxel-wise whole-brain ALFF analysis identified the bilateral caudate nucleus, putamen, and motor cortex as HD-specific brain regions. ALFF changes in the caudate nucleus and putamen correlated with their respective volumetric atrophy, whereas ALFF changes in the motor cortex preceded its atrophy in the HD preclinical stage. Subsequently, DCM revealed increased inhibitory connectivity from the bilateral caudate nucleus to the motor cortex in HD participants compared to controls. Moreover, compared to preclinical mutation carriers, symptomatic patients showed decreased inhibitory connectivity from the right putamen to the bilateral caudate nucleus, with nonlinear relationships with motor scores.
conclusionsOur results indicate that striatal atrophy and hyper-inhibition of caudate-motorial connectivity might contribute to the regional function alterations in HD. Furthermore, disruption of inhibitory connectivity in the striatal-motor circuit may play an important role in the emergence of motor symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.