Evidence map›Paper›PMID 40509473›Full record

ReviewFoods (Basel, Switzerland)2025

Fermented Dairy Products as Precision Modulators of Gut Microbiota and Host Health: Mechanistic Insights, Clinical Evidence, and Future Directions.

Yuan Gao, Yanyan Liu, Tingting Ma, Qimeng Liang, Junqi Sun, Xiaomeng Wu, Yinglong Song, Hui Nie, Jun Huang, Guangqing Mu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  16. Evolutionary Screening ofMicroorganisms · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuan GaoSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.ORCID 0000-0002-3931-4272
Yanyan LiuSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Tingting MaSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Qimeng LiangSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Junqi SunSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Xiaomeng WuDalian Probiotics Function Research Key Laboratory, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
Yinglong SongDalian Probiotics Function Research Key Laboratory, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
Hui NieGuangxi Key Laboratory of Health Care Food Science and Technology, Hezhou University, Hezhou 542899, China.
Jun HuangSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Guangqing MuDalian Probiotics Function Research Key Laboratory, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.ORCID 0000-0001-9356-753X

Funding

National Key Research and Development Program 2022YFD2101503National Natural Science Foundation of China 32302032Natural Science Foundation of Guangxi, China 2020GXNSFBA297083
6 · The paper itself

Abstract

Dairy products-encompassing yogurt, kefir, cheese, and cultured milk beverages-are emerging as versatile, food-based modulators of gut microbiota and host physiology. This review synthesizes mechanistic insights demonstrating how live starter cultures and their fermentation-derived metabolites (short-chain fatty acids, bioactive peptides, and exopolysaccharides) act synergistically to enhance microbial diversity, reinforce epithelial barrier integrity via upregulation of tight-junction proteins, and modulate immune signaling. Clinical evidence supports significant improvements in metabolic parameters (fasting glucose, lipid profiles, blood pressure) and reductions in systemic inflammation across metabolic syndrome, hypertension, and IBS cohorts. We highlight critical modulatory factors-including strain specificity, host enterotypes and FUT2 genotype, fermentation parameters, and matrix composition-that govern probiotic engraftment, postbiotic yield, and therapeutic efficacy. Despite promising short-term outcomes, current studies are limited by heterogeneous designs and brief intervention periods, underscoring the need for long-term, adaptive trials and integrative multi-omics to establish durability and causality. Looking forward, precision nutrition frameworks that harness baseline microbiota profiling, host genetics, and data-driven fermentation design will enable bespoke fermented dairy formulations, transforming these traditional foods into next-generation functional matrices for targeted prevention and management of metabolic, inflammatory, and neuroimmune disorders.

Indexed as

fermented dairy productsgut microbiota modulationhost–microbiome interactionspostbioticsprecision nutrition

Identifiers

PMID40509473
PMCPMC12154003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.