Evidence map›Paper›PMID 40509443›Full record

ArticleFoods (Basel, Switzerland)2025

Sustainable Exploitation of Apple By-Products: A Retrospective Analysis of Pilot-Scale Extraction Tests Using Hydrodynamic Cavitation.

Luca Tagliavento, Tiziana Nardin, Jasmine Chini, Nicola Vighi, Luca Lovatti, Lara Testai, Francesco Meneguzzo, Roberto Larcher, Federica Zabini

Abstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luca TagliaventoHyRes S.r.l., Via Salvator Rosa 18, 82100 Benevento, Italy.ORCID 0000-0002-0728-403X
Tiziana NardinTechnological Transfer Center, FEM-IASMA Fondazione Edmund Mach, Istituto Agrario di San Michele all'Adige, Via E. Mach 1, 38010 San Michele all'Adige, Italy.ORCID 0000-0001-7177-1062
Jasmine ChiniConsorzio Melinda SCA, Via Trento 200/9, 38023 Cles, Italy.
Nicola VighiConsorzio Melinda SCA, Via Trento 200/9, 38023 Cles, Italy.
Luca LovattiCIF Consorzio Innovazione Frutta, Via Edmondo Mach 1, 38010 San Michele all'Adige, Italy.ORCID 0000-0001-7696-9297
Lara TestaiDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0003-2431-6248
Francesco MeneguzzoInstitute of Bioeconomy, National Research Council of Italy, Via Madonna del Piano 10, 50019 Florence, Italy.ORCID 0000-0002-5952-9166
Roberto LarcherTechnological Transfer Center, FEM-IASMA Fondazione Edmund Mach, Istituto Agrario di San Michele all'Adige, Via E. Mach 1, 38010 San Michele all'Adige, Italy.ORCID 0000-0002-4784-8389
Federica ZabiniInstitute of Bioeconomy, National Research Council of Italy, Via Madonna del Piano 10, 50019 Florence, Italy.ORCID 0000-0003-1505-0839

Funding

Italian Ministry of University and Research PE0000003, Concession Decree No. 1550 of 11 October 2022Ministry of Enterprises and Made in Italy CUP C77B24000000008 of 10 March 2022National Research Council FOE-2021 DBA.AD005.225
6 · The paper itself

Abstract

Apple by-products (APs) consist of whole defective fruits discarded from the market and pomace resulting from juice squeezing and puree production, which are currently underutilized or disposed of due to the lack of effective and scalable extraction methods. Bioactive compounds in APs, especially phlorizin, which is practically exclusive to the apple tree, are endowed with preventive and therapeutic potential concerning chronic diseases such as cardiovascular diseases, metabolic diseases, and specific types of cancer. This study investigated the exploitation of APs using hydrodynamic cavitation (HC) for the extraction step and water as the only solvent. High-temperature extraction (>80 °C) was needed to inactivate the polyphenol oxidase; a strict range of the cavitation number (around 0.07) was identified for extraction optimization; less than 20 min were sufficient for the extraction of macro- and micro-nutrients up to nearly their potential level, irrespective of the concentration of fresh biomass up to 50% of the water mass. The energy required to produce 30 to 100 g of dry extract containing 100 mg of phlorizin was predicted at around or less than 1 kWh, with HC contributing for less than 2.5% to the overall energy balance due to the efficient extraction process.

Indexed as

apple by-productsbioactive compoundsbioeconomygreen extractionhydrodynamic cavitationsustainability

Identifiers

PMID40509443
PMCPMC12154374

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.