Evidence map›Paper›PMID 40509380›Full record

ArticleFoods (Basel, Switzerland)2025

High-Fat Diet-Induced Mild Obesity Alters the Activation of T Cells and Maintains Intestinal Homeostasis in Food Allergy Animal Model.

Fan Yang, Ruofan Xie, Meijia Huang, Chunqiu Hu, Yong Wu, Xin Li, Hongbing Chen

Abstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fan YangCollege of Food Science & Technology, Nanchang University, Nanchang 330047, China.
Ruofan XieCollege of Food Science & Technology, Nanchang University, Nanchang 330047, China.
Meijia HuangSchool of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, China.
Chunqiu HuDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei 230032, China.ORCID 0009-0005-9990-3633
Yong WuCollege of Food Science & Technology, Nanchang University, Nanchang 330047, China.ORCID 0000-0001-9840-940X
Xin LiCollege of Food Science & Technology, Nanchang University, Nanchang 330047, China.ORCID 0000-0002-9466-2659
Hongbing ChenCollege of Food Science & Technology, Nanchang University, Nanchang 330047, China.ORCID 0000-0002-4845-383X

Funding

National Natural Science Foundation of China 31872887
6 · The paper itself

Abstract

A close association between obesity and food allergies has been described, but from the perspective of T cell differentiation, controversial findings exist regarding the impact of high-fat diet (HFD) feeding on the development of food allergies. Our study aimed to explore the relationship between HFD-induced mild obesity and food allergy development in female BALB/c mice. Following 18 weeks of HFD feeding, experimental animals demonstrated a 10.92% body weight gain accompanied by a 32.45% elevation in total cholesterol levels and a 39.50% increase in low-density lipoprotein-cholesterol levels. Upon allergen challenge, control diet (COD)-fed mice developed obvious food allergy symptoms and hypothermia, which were slightly alleviated in HFD-fed mice. Flow cytometry revealed that splenocytes from HFD-fed mice exhibited a 102.32% increase in CD4

Indexed as

food allergyhigh-fat dietimmune responseintestinal barrier

Identifiers

PMID40509380
PMCPMC12154341

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.