Synthesis of Cyclic Hexapeptides via the Hydrazide Method and Evaluation of Their Antibacterial Activities.

Yunfei Cui, Meng Liu, Binghui Ruan, Zhouyuji Liao, Xue Tang, Dongting Zhangsun, Yong Wu, Sulan Luo

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Yunfei CuiGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.

Meng LiuGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.

Binghui RuanGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.

Zhouyuji LiaoGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.

Xue TangGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.

Dongting ZhangsunGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.

Yong WuGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.ORCID 0000-0001-6395-4213

Sulan LuoGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.ORCID 0000-0002-9358-5970

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) have emerged as promising candidates in the fight against multidrug-resistant pathogens due to their broad-spectrum antimicrobial activity and low potential for resistance development. However, their clinical application is limited by poor stability and susceptibility to enzymatic degradation. This study aims to address these limitations by synthesizing a series of cyclic hexapeptides using the hydrazide method and evaluating their antimicrobial activity and stability. The hydrazide method facilitated the synthesis of 11 cyclic peptides through a reaction between C-terminal hydrazides and cysteine-containing peptides. Antimicrobial assays showed that Cy-f2 and Cy-f4 exhibited potent inhibitory effects against different kinds of bacteria, including

Indexed as

Anti-Bacterial AgentsHydrazinesPeptides, CyclicEscherichia coliHemolysisHumansMicrobial Sensitivity TestsStaphylococcus aureusAnti-Bacterial AgentsHydrazinesPeptides, CyclicAMPsantimicrobial peptideshydrazide-based chemistrystability

Identifiers

PMID40509331

DOI10.3390/molecules30112444

PMCPMC12156185

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.