Evidence map›Paper›PMID 40509324›Full record

ArticleMolecules (Basel, Switzerland)2025

Green and Efficient Synthetic Protocol for 1,3,5-Triazine Derivatives with Anticancer Potential Against Colorectal Cancer.

Julia Chrzan, Anna Karolina Drabczyk, Izabela Siemińska, Monika Baj-Krzyworzeka, Katarzyna Ewa Greber, Jolanta Jaśkowska, Damian Kułaga, Krzesimir Ciura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julia ChrzanDepartment of Organic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska Street, 31-155 Krakow, Poland.ORCID 0009-0001-6101-2107
Anna Karolina DrabczykDepartment of Organic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska Street, 31-155 Krakow, Poland.ORCID 0000-0002-4629-2059
Izabela SiemińskaDepartment of Organic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska Street, 31-155 Krakow, Poland.
Monika Baj-KrzyworzekaDepartment of Clinical Immunology, Medical College, Jagiellonian University, 30-663 Krakow, Poland.
Katarzyna Ewa GreberDepartment of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdansk, 107 General Jozef Haller Avenue, 80-416 Gdansk, Poland.
Jolanta JaśkowskaDepartment of Organic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska Street, 31-155 Krakow, Poland.ORCID 0000-0001-6855-3531
Damian KułagaDepartment of Organic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska Street, 31-155 Krakow, Poland.ORCID 0000-0001-8779-4170
Krzesimir CiuraDepartment of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdansk, 107 General Jozef Haller Avenue, 80-416 Gdansk, Poland.ORCID 0000-0001-6187-6039

Funding

National Center for Research and Development LIDER/41/0206/L-12/20/NCBR/2021National Science Centre of Poland 2022/47/D/NZ7/01043
6 · The paper itself

Abstract

Colorectal cancer (CRC) remains a major global health challenge, necessitating the development of more effective and environmentally sustainable treatments. This study presents a novel green synthetic protocol for 1,3,5-triazine derivatives with anticancer potential, employing both microwave-assisted and ultrasound-assisted methods. The synthesis was optimized using 4-chloro-

Indexed as

Antineoplastic AgentsColorectal NeoplasmsGreen Chemistry TechnologyTriazinesCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansMicrowavesMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsTriazines1,3,5-triazineADMEanticancer agentscolorectal cancercytotoxicitydrug likenessgreen chemistrymicrowave-assisted synthesisphase-transfer catalysissonochemistry

Identifiers

PMID40509324
PMCPMC12157728

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.