Evidence map›Paper›PMID 40509267›Full record

ArticleMolecules (Basel, Switzerland)2025

Assessing Diazinon Exposure: A GC-MS/MS Validation Study of BChE Measurement by Point-of-Care Testing and Enzyme Multiplied Immunoassay Technique.

Andreea-Camelia Hîrjău, Mihaela Emanuela Crăciun, Ilinca-Mihaela Marandiuc, Gabriel-Lucian Radu

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andreea-Camelia Hîrjău"Cantacuzino" National Institute for Medical-Military Research and Development, 050096 Bucharest, Romania.ORCID 0009-0007-1538-0316
Mihaela Emanuela CrăciunDepartment of Analytical Chemistry and Environmental Engineering, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania.
Ilinca-Mihaela Marandiuc"Cantacuzino" National Institute for Medical-Military Research and Development, 050096 Bucharest, Romania.
Gabriel-Lucian RaduDoctoral School of "Chemical Engineering and Biotechnologies", National University of Science and Technology Politehnica Bucharest, 011061 Bucharest, Romania.ORCID 0000-0002-4385-1177

Funding

Romanian Ministry of National Defense
6 · The paper itself

Abstract

This study addresses the challenge of accurately assessing diazinon exposure in suspected self-poisoning cases. We evaluated butyrylcholinesterase (BChE) levels using a point-of-care (POCT) whole blood assay (adapted Ellman method) and compared it with the standard plasma Enzyme Multiplied Immunoassay Technique (EMIT). Diazinon exposure in four patients was confirmed using a validated gas chromatography-tandem mass spectrometry (GC-MS/MS) method with multiple reaction monitoring (MRM). A strong positive correlation was observed between POCT and EMIT BChE activity (r = 0.9638,

Indexed as

ButyrylcholinesteraseDiazinonPoint-of-Care TestingAdultFemaleGas Chromatography-Mass SpectrometryHumansImmunoenzyme TechniquesMaleMiddle AgedTandem Mass SpectrometryButyrylcholinesteraseDiazinonbutyrylcholinesterase (BChE)diazinonemergency medicineEMIT immunoassayorganophosphate poisoningpoint-of-care testing (POCT)

Identifiers

PMID40509267
PMCPMC12156338

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.