Evidence map›Paper›PMID 40509206›Full record

ArticleMolecules (Basel, Switzerland)2025

Exploration of a Novel Catalytic Approach for Synthesizing Glycolide and ε-Caprolactone Copolymers and Their Application as Carriers for Paclitaxel.

Rafał Wyrębiak, Ramona Figat, Ewa Oledzka, Adam Kasiński, Karolina Kędra, Anna Laskowska, Marcin Sobczak

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rafał WyrębiakDepartment of Pharmaceutical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland.ORCID 0000-0002-7062-886X
Ramona FigatDepartment of Toxicology and Food Science, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland.ORCID 0000-0003-2312-6768
Ewa OledzkaDepartment of Pharmaceutical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland.ORCID 0000-0003-0660-3315
Adam KasińskiDepartment of Pharmaceutical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland.ORCID 0000-0003-0187-9638
Karolina KędraInstitute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52 Str., 01-224 Warsaw, Poland.ORCID 0000-0002-3696-1618
Anna LaskowskaDepartment of Pharmaceutical Microbiology and Bioanalysis, Centre for Preclinical Research, Medical University of Warsaw, Banacha 1b Str., 02-097 Warsaw, Poland.ORCID 0000-0002-0575-2514
Marcin SobczakDepartment of Pharmaceutical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland.ORCID 0000-0002-7362-8881

Funding

Medical University of Warsaw FW231/1/F/MB/N/20
6 · The paper itself

Abstract

Biodegradable polyesters serve as matrices in pharmaceutical applications for the controlled release of therapeutic agents. These polymers are essential in the advancement of drug delivery systems (DDSs) that facilitate the gradual drug release over a predetermined duration. Therefore, this study introduces the novel use of a diethyl zinc/propyl gallate catalytic system to synthesize glycolide/ε-caprolactone copolymers (PGCL) for subsequent biomedical applications. A total of twenty-four biodegradable copolymeric matrices, characterized by a highly random microstructure and an average molecular weight (

Indexed as

CaproatesDrug CarriersLactonesPaclitaxelPolyestersPolymersCatalysisDrug Delivery SystemsDrug LiberationHemolysisHumansCaproatescaprolactoneDrug CarriersLactonesPaclitaxelPolyestersPolymersanti-cancer drug delivery systemsbiomaterialsbiomedical polyesterspaclitaxelε-caprolactone and glycolide copolymers

Identifiers

PMID40509206
PMCPMC12156253

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.